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Anti-CDK5RAP3 Antibody

品牌：Antibodies

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規(guī)格：100μl

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Anti-CDK5RAP3 Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-CDK5RAP3 Antibody See all CDK5RAP3 primary antibodies
Description:	Rabbit polyclonal antibody to CDK5RAP3
Specificity:	The antibody detects endogenous levels of total CDK5RAP3 protein.
Applications:	WB, IHC
Reactivity:	Human
Immunogen:	Fusion protein corresponding to a region derived from internal residues of human CDK5 regulatory subunit associated protein 3
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	2.6mg / ml
Formulation:	Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage:	Store at -20?C

Target

Function:	Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation (PubMed:12054757, PubMed:12737517). Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation (PubMed:17785205, PubMed:20228063). Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint (PubMed:15790566, PubMed:19223857). Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation (PubMed:16173922). May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress (PubMed:23152784). May also play a role in the rupture of the nuclear envelope during apoptosis (PubMed:23478299). May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1 (PubMed:21283629).
Tissue Specificity:	Ubiquitously expressed (PubMed:12054757, PubMed:10721722). Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform 3 is expressed in kidney, liver, skeletal muscle and placenta (PubMed:12737517).
Sequence Similarities:	Belongs to the CDK5RAP3 family.
Post-Translational Modification:	May be phosphorylated by CDK5.
Cellular Location:	Nucleus. Cytoplasm. Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome. Colocalizes and associates with microtubules.
Database Links:	Entrez Gene: 80279?Human Omim: 608202?Human SwissProt: Q96JB5?Human Unigene: 20157?Human
Synonyms:	C53 Antibody CDK5 activator binding protein C53 Antibody CDK5 activator-binding protein C53 Antibody CDK5 regulatory subunit associated protein 3 Antibody CDK5 regulatory subunit-associated protein 3 Antibody CDK5RAP3 Antibody CK5P3_HUMAN Antibody HSF 27 Antibody HSF27 Antibody IC53 Antibody Ischemic heart CDK5 activator binding protein C53 Antibody LXXLL/leucine zipper containing ARFbinding protein Antibody LZAP Antibody MST016 Antibody OK/SW cl.114 Antibody PP1553 Antibody Protein HSF-27 Antibody
Information:	Target information shown above is from the UniProt Consortium.