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Anti-Cdc6 (phospho-S54) Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-Cdc6 (phospho-S54) Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-Cdc6 (phospho-S54) Antibody See all Cdc6 primary antibodies
Description:	Rabbit polyclonal antibody to Cdc6 (phospho-S54)
Specificity:	p-Cdc6 (S54) pAb detects endogenous levels of Cdc6 only when phosphorylated at Ser54.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic phosphopeptide derived from human Cdc6 around the phosphorylation site of Serine 54.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 62 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.

Target

Function:	Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.
Involvement in Disease:	Meier-Gorlin syndrome 5: A syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and absent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal.
Sequence Similarities:	Belongs to the CDC6/cdc18 family.
Cellular Location:	Nucleus. Cytoplasm. The protein is nuclear in G1 and cytoplasmic in S-phase cells (PubMed:9566895).
Database Links:	Entrez Gene: 990?Human Entrez Gene: 23834?Mouse Entrez Gene: 360621?Rat Omim: 602627?Human SwissProt: Q99741?Human SwissProt: O89033?Mouse Unigene: 405958?Human Unigene: 20912?Mouse Unigene: 219688?Rat
Synonyms:	Cdc 18L Antibody Cdc 6 Antibody CDC18 (cell division cycle 18, S.pombe, homolog) like Antibody CDC18 (S.pombe) Antibody Cdc18 related protein Antibody CDC18(S.pombe) Antibody Cdc18-related protein Antibody Cdc18L Antibody Cdc6 Antibody CDC6 cell division cycle 6 homolog Antibody CDC6 related protein Antibody CDC6-related protein Antibody Cdc6p Antibody CDC6_HUMAN Antibody CELL CYCLE CONTROLLER CDC6 Antibody Cell division control protein 6 Antibody Cell division control protein 6 homolog Antibody Cell division cycle 6 homolog Antibody Cell division cycle 6 homolog (S. cerevisiae) Antibody Cell division cycle 6, S. cerevisiae, homolog of Antibody HsCDC 6 Antibody HsCDC18 Antibody HsCDC6 Antibody p62 Antibody p62(cdc 6) Antibody p62(cdc6) Antibody
Information:	Target information shown above is from the UniProt Consortium.