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Anti-CDC25A (Ab-178) Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-CDC25A (Ab-178) Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-CDC25A (Ab-178) Antibody See all CDC25A primary antibodies
Description:	Rabbit polyclonal antibody to CDC25A (Ab-178)
Specificity:	The antibody detects endogenous levels of total CDC25A protein.
Applications:	WB
Reactivity:	Human
Immunogen:	Synthesized non-phosphopeptide derived from human CDC25A around the phosphorylation site of serine 178 (Q-N-S(p)-A-P).
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1.0mg / ml
Formulation:	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20?C

Target

Function:	Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro.
Sequence Similarities:	Belongs to the MPI phosphatase family.
Post-Translational Modification:	Phosphorylated by CHEK1 on Ser-76, Ser-124, Ser-178, Ser-279, Ser-293 and Thr-507 during checkpoint mediated cell cycle arrest. Also phosphorylated by CHEK2 on Ser-124, Ser-279, and Ser-293 during checkpoint mediated cell cycle arrest. Phosphorylation on Ser-178 and Thr-507 creates s for YWHAE/14-3-3 epsilon which inhibits CDC25A. Phosphorylation on Ser-76, Ser-124, Ser-178, Ser-279 and Ser-293 may also promote ubiquitin-dependent proteolysis of CDC25A by the SCF complex. Phosphorylation of CDC25A at Ser-76 by CHEK1 primes it for subsequent phosphorylation at Ser-79, Ser-82 and Ser-88 by NEK11. Phosphorylation by NEK11 is required for BTRC-mediated polyubiquitination and degradation. Phosphorylation by PIM1 leads to an increase in phosphatase activity. Phosphorylated by PLK3 following DNA damage, leading to promote its ubiquitination and degradation.
Database Links:	Entrez Gene: 993?Human Omim: 116947?Human SwissProt: P30304?Human Unigene: 437705?Human
Synonyms:	Cdc 25a Antibody Cdc25A Antibody CDC25A2 Antibody CDC25A2 CAG isoform Antibody Cell division cycle 25 homolog A (S. pombe) Antibody Cell division cycle 25A Antibody Cell division cycle 25A isoform a Antibody Cell division cycle 25A isoform b Antibody D9Ertd393e Antibody Dual specificity phosphatase Cdc25A Antibody M phase inducer phosphatase 1 Antibody M-phase inducer phosphatase 1 Antibody MGC115549 Antibody MPIP1_HUMAN Antibody
Information:	Target information shown above is from the UniProt Consortium.