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Anti-Cdc16 (K556) Antibody

品牌：Antibodies

貨號(hào)：

規(guī)格：50μl

貨期：

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Anti-Cdc16 (K556) Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Name:	Anti-Cdc16 (K556) Antibody See all Cdc16 primary antibodies
Description:	Rabbit polyclonal antibody to Cdc16 (K556)
Specificity:	Cdc16 (K556) pAb detects endogenous levels of Cdc16 protein.
Applications:	WB, IHC, IF
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 530-580 of Human Cdc16.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 72 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Function:	Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
Sequence Similarities:	Belongs to the APC6/CDC16 family.
Post-Translational Modification:	Phosphorylated. Phosphorylation on Ser-560 occurs specifically during mitosis.
Cellular Location:	Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome. Cytoplasm > Cytoskeleton > Spindle. Colocalizes with CDC27 to the centrosome at all stages of the cell cycle and to the mitotic spindle.