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Anti-CD95 Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-CD95 Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-CD95 Antibody See all CD95 primary antibodies
Description:	Rabbit polyclonal antibody to CD95
Specificity:	CD95 Polyclonal Antibody detects endogenous levels of CD95 protein.
Applications:	WB, IHC, ELISA
Reactivity:	Human
Immunogen:	Synthesized peptide derived from the C-terminal region of human CD95.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1mg / ml
Formulation:	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage:	Store at -20?C / 1 year

Target

Function:	Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
Tissue Specificity:	Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6.
Involvement in Disease:	Autoimmune lymphoproliferative syndrome 1A: A disorder of apoptosis that manifests in early childhood and results in the accumulation of autoreactive lymphocytes. It is characterized by non-malignant lymphadenopathy with hepatosplenomegaly, and autoimmune hemolytic anemia, thrombocytopenia and neutropenia.
Post-Translational Modification:	N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.
Cellular Location:	Cell membrane.
Database Links:	Entrez Gene: 355?Human Omim: 134637?Human SwissProt: P25445?Human Unigene: 244139?Human
Synonyms:	ALPS 1A Antibody ALPS1A Antibody APO 1 Antibody Apo 1 antigen Antibody APO 1 cell surface antigen Antibody Apo-1 antigen Antibody APO1 Antibody Apo1 antigen Antibody APO1 cell surface antigen Antibody Apoptosis antigen 1 Antibody Apoptosis mediating surface antigen FAS Antibody Apoptosis-mediating surface antigen FAS Antibody APT 1 Antibody APT1 Antibody CD 95 Antibody CD 95 antigen Antibody CD95 Antibody CD95 antigen Antibody Delta Fas Antibody Delta Fas/APO 1/CD95 Antibody Delta Fas/APO1/CD95 Antibody Fas Antibody Fas (TNF receptor superfamily, member 6) Antibody FAS 1 Antibody FAS 827dupA Antibody Fas AMA Antibody FAS Antigen Antibody Fas cell surface death receptor Antibody FAS1 Antibody FASLG receptor Antibody FASTM Antibody sFAS Antibody Surface antigen APO1 Antibody TNF receptor superfamily, member 6 Antibody TNFRSF 6 Antibody TNFRSF6 Antibody TNR6_HUMAN Antibody Tumor necrosis factor receptor superfamily member 6 Antibody
Information:	Target information shown above is from the UniProt Consortium.