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Anti-CD62P Antibody

品牌：Antibodies

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規(guī)格：100μg

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Anti-CD62P Antibody

商品詳情參考文獻相關資料

Overview

Name:	Anti-CD62P Antibody See all CD62P primary antibodies
Description:	Mouse monoclonal (AK4) antibody to CD62P.
Specificity:	The antibody HI62P recognizes CD62P (P-selectin), a 140 kD single chain type I transmembrane glycoprotein present in secretory alpha-granules in platelets, in Weibel-Palade bodies in endothelial cells and in megakaryocytes; it is relocated to the plasma membrane upon activation.
Applications:	FC, IP, WB, ICC, FUNC
Reactivity:	Human, Non-Human Primates
Immunogen:	Human platelets.
Host:	Mouse
Clonality:	Monoclonal
Clone:	AK4
Isotype:	IgG1
Conjugate:	Unconjugated
Purification:	Protein A chromatography.
Concentration:	1 mg/ml
Purity:	> 95% (by SDS-PAGE)
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.4, without Azide (0.2 μm filter sterilised). Endotoxin level is less than 0.01 EU/μg of the protein, as determined by the LAL test.
Storage:	Store at 2-8°C.

Target

Function:	Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1.
Tissue Specificity:	Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface.
Involvement in Disease:	Ischemic stroke: A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
Sequence Similarities:	Belongs to the selectin/LECAM family.
Cellular Location:	Membrane.
Database Links:	Entrez Gene: 6403?Human Omim: 173610?Human SwissProt: P16109?Human Unigene: 73800?Human
Synonyms:	Antigen CD62 Antibody CD62 Antibody CD62 antigen like family member P Antibody CD62 antigen-like family member P Antibody CD62P Antibody FLJ45155 Antibody GMP 140 Antibody GMP-140 Antibody GMP140 Antibody GMRP Antibody Granule membrane protein 140 Antibody Granule membrane protein 140kDa Antibody Granulocyte membrane protein Antibody GRMP Antibody LECAM 3 Antibody LECAM3 Antibody Leukocyte endothelial cell adhesion molecule 3 Antibody Leukocyte-endothelial cell adhesion molecule 3 Antibody LYAM3_HUMAN Antibody P selectin Antibody P-selectin Antibody PADGEM Antibody Platelet activation dependent granule external membrane protein Antibody Platelet activation dependent granule-external membrane protein Antibody Platelet alpha granule membrane protein Antibody PSEL Antibody Selectin P Antibody Selectin P (granule membrane protein 140kDa antigen CD62) Antibody Selectin P (granule membrane protein 140kDa, antigen CD62) Antibody SELP Antibody
Information:	Target information shown above is from the UniProt Consortium.