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Anti-CD3 zeta (Phospho-Tyr72) Antibody

品牌：Antibodies

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規(guī)格：100μg

貨期：

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Anti-CD3 zeta (Phospho-Tyr72) Antibody

商品詳情參考文獻相關資料

Overview

Name:	Anti-CD3 zeta (Phospho-Tyr72) Antibody See all CD3 zeta primary antibodies
Description:	Mouse monoclonal (EM-26) antibody to CD3 zeta (Phospho-Tyr72).
Specificity:	The mouse monoclonal antibody EM-26 recognizes phosphorylated tyrosine 72 of CD3 zeta chain (CD247), which is a component of TCR/CD3 complex expressed on T cells.
Applications:	FC, WB, ICC
Reactivity:	Human, Mouse
Immunogen:	A phospho-specific peptide corresponding to the amino acids surrounding tyrosine 72 of mouse CD3 zeta linked to KLH.
Host:	Mouse
Clonality:	Monoclonal
Clone:	EM-26
Isotype:	IgG1
Conjugate:	Unconjugated
Purification:	Protein A chromatography.
Concentration:	1 mg/ml
Purity:	> 95% (by SDS-PAGE)
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.4, with 15mM Sodium Azide.
Storage:	Store at 2-8°C.

Target

Function:	Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. CD3Z ITAMs phosphorylation creates multiple docking sites for the protein kinase ZAP70 leading to ZAP70 phosphorylation and its conversion into a catalytically active enzyme. Plays an important role in intrathymic T-cell differentiation. Additionally, participates in the activity-dependent synapse formation of retinal ganglion cells (RGCs) in both the retina and dorsal lateral geniculate nucleus (dLGN).
Tissue Specificity:	CD3Z is expressed in normal lymphoid tissue and in peripheral blood mononuclear cells (PBMCs). Expressed also in retinal ganglion cells (PubMed:20188655).
Sequence Similarities:	Belongs to the CD3Z/FCER1G family.
Post-Translational Modification:	Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8.
Cellular Location:	Membrane.
Database Links:	Entrez Gene: 919?Human Entrez Gene: 12503?Mouse Omim: 186780?Human SwissProt: P20963?Human SwissProt: P24161?Mouse Unigene: 156445?Human Unigene: 217308?Mouse Unigene: 475205?Mouse
Synonyms:	4930549J05Rik Antibody A430104F18Rik Antibody AW552088 Antibody CD247 Antibody CD247 antigen Antibody Cd247 molecule Antibody Cd3 Antibody CD3 antigen, zeta polypeptide, isoform CRA_b Antibody CD3 antigen, zeta subunit Antibody CD3 zeta Antibody CD3-eta Antibody CD3H Antibody CD3Q Antibody Cd3z Antibody CD3Z antigen zeta polypeptide (TiT3 complex) Antibody CD3zeta Antibody CD3zeta chain Antibody CD3Z_HUMAN Antibody MGC140430 Antibody T cell receptor T3 zeta chain Antibody T cell surface glycoprotein CD3 zeta chain Antibody T-cell antigen receptor complex, zeta subunit of CD3 Antibody T-cell receptor T3 zeta chain Antibody T-cell surface glycoprotein CD3 zeta chain Antibody T3z Antibody TCR zeta chain Antibody TCRk Antibody TCRZ Antibody TCRzeta Antibody
Information:	Target information shown above is from the UniProt Consortium.