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Anti-CD2AP Antibody

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Anti-CD2AP Antibody

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Overview

Name:	Anti-CD2AP Antibody See all CD2AP primary antibodies
Description:	Rabbit polyclonal antibody to CD2AP
Specificity:	The antibody detects endogenous levels of total CD2AP protein.
Applications:	WB, IHC
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to a region derived from internal residues of human CD2-associated protein
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	3mg / ml
Formulation:	Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage:	Store at -20?C

Target

Function:	Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation. May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis.
Tissue Specificity:	Widely expressed in fetal and ***** tissues.
Involvement in Disease:	Focal segmental glomerulosclerosis 3: A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and progressive decline in renal function. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation.
Post-Translational Modification:	Phosphorylated on tyrosine residues; probably by c-Abl, Fyn and c-Src.
Cellular Location:	Cytoplasm > Cytoskeleton. Cell projection > Ruffle. Colocalizes with F-actin and BCAR1/p130Cas in membrane ruffles. Located at podocyte slit diaphragm between podocyte foot processes (By similarity). During late anaphase and telophase, concentrates in the vicinity of the midzone microtubules and in the midbody in late telophase.
Database Links:	Entrez Gene: 23607?Human Omim: 604241?Human SwissProt: Q9Y5K6?Human Unigene: 485518?Human
Synonyms:	Adapter protein CMS Antibody AL024079 Antibody C78928 Antibody Cas ligand with multiple SH3 domains Antibody CD2 associated protein Antibody CD2-associated protein Antibody CD2AP Antibody CD2AP_HUMAN Antibody CMS Antibody Mesenchyme to epithelium transition protein with SH3 domains 1 Antibody METS 1 Antibody Mets1 Antibody
Information:	Target information shown above is from the UniProt Consortium.