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Anti-CD27 Antibody

品牌：Antibodies

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規(guī)格：100T

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Anti-CD27 Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-CD27 Antibody See all CD27 primary antibodies
Description:	Mouse monoclonal (LT27) antibody to CD27 (PE).
Specificity:	The antibody LT27 reacts with CD27 (T14), a 50-55 kDa type I transmembrane glycoprotein (member of the TNF-receptor superfamily) expressed on medullary thymocytes, peripheral T lymphocytes, some B lymphocytes and NK cells.
Applications:	FC
Reactivity:	Human
Immunogen:	Human peripheral blood lymphocytes.
Host:	Mouse
Clonality:	Monoclonal
Clone:	LT27
Isotype:	IgG2a
Conjugate:	PE
Purification:	Size exclusion chromatography.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline with 15mM Sodium Azide.
Storage:	Store in the dark at 2-8°C. Avoid prolonged exposure to light.

Target

Function:	Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.
Tissue Specificity:	Found in most T-lymphocytes.
Involvement in Disease:	Lymphoproliferative syndrome 2: An autosomal recessive immunodeficiency disorder associated with persistent symptomatic EBV viremia, hypogammaglobulinemia, and impaired T-cell-dependent B-cell responses and T-cell dysfunction. The phenotype is highly variable, ranging from asymptomatic borderline-low hypogammaglobulinemia, to a full-blown symptomatic systemic inflammatory response with life-threatening EBV-related complications, including hemophagocytic lymphohistiocytosis, a lymphoproliferative disorder, and malignant lymphoma requiring stem cell transplantation.
Post-Translational Modification:	Phosphorylated.
Cellular Location:	Membrane.
Database Links:	Entrez Gene: 939?Human Omim: 186711?Human SwissProt: P26842?Human Unigene: 355307?Human
Synonyms:	CD 27 Antibody CD27 Antibody CD27 antigen Antibody CD27 molecule Antibody CD27L receptor Antibody CD27_HUMAN Antibody LPFS2 Antibody MGC20393 Antibody OTTHUMP00000238557 Antibody S152 Antibody T cell activation antigen CD27 Antibody T cell antivation antigen S152 Antibody T-cell activation antigen CD27 Antibody T14 Antibody TNFRSF 7 Antibody TNFRSF7 Antibody TNFSF7 Antibody Tp 55 Antibody Tp55 Antibody Tumor necrosis factor receptor superfamily member 7 Antibody
Information:	Target information shown above is from the UniProt Consortium.