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Anti-CD235a Antibody

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Anti-CD235a Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-CD235a Antibody See all Glycophorin A primary antibodies
Description:	Mouse monoclonal (HIR2) antibody to CD235a (PE).
Specificity:	The antibody HIR2 recognizes N-terminal portion of glycophorin A (and weakly of glycophorin B). Its antigen is expressed on early erythroblasts, late erythroblasts, erythroblasts, mature erythrocytes and the cells of erythroid cell lines K562 and HEL, but not on all other cells.
Applications:	FC, IHC-Fr, AGG
Reactivity:	Human
Immunogen:	Synthetic peptide (Human, N-terminal).
Host:	Mouse
Clonality:	Monoclonal
Clone:	HIR2
Isotype:	IgG2b
Conjugate:	PE
Purification:	Size exclusion chromatography.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline with 15mM Sodium Azide.
Storage:	Store in the dark at 2-8°C. Avoid prolonged exposure to light.

Target

Function:	Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. Is a receptor for influenza virus. Is a receptor for Plasmodium falciparum erythrocyte-binding antigen 175 (EBA-175); binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. Appears to be a receptor for Hepatitis A virus (HAV).
Sequence Similarities:	Belongs to the glycophorin A family.
Post-Translational Modification:	The major O-linked glycan are NeuAc-alpha-(2-3)-Gal-beta-(1-3)-[NeuAc-alpha-(2-6)]-GalNAcOH (about 78 %) and NeuAc-alpha-(2-3)-Gal-beta-(1-3)-GalNAcOH (17 %). Minor O-glycans (5 %) include NeuAc-alpha-(2-3)-Gal-beta-(1-3)-[NeuAc-alpha-(2-6)]-GalNAcOH NeuAc-alpha-(2-8)-NeuAc-alpha-(2-3)-Gal-beta-(1-3)-GalNAcOH. About 1% of all O-linked glycans carry blood group A, B and H determinants. They derive from a type-2 precursor core structure, Gal-beta-(1,3)-GlcNAc-beta-1-R, and the antigens are synthesized by addition of fucose (H antigen-specific) and then N-acetylgalactosamine (A antigen-specific) or galactose (B antigen-specific). Specifically O-linked-glycans are NeuAc-alpha-(2-3)-Gal-beta-(1-3)-GalNAcOH-(6-1)-GlcNAc-beta-(4-1)-[Fuc-alpha-(1-2)]-Gal-beta-(3-1)-GalNAc-alpha (about 1%, B antigen-specific) and NeuAc-alpha-(2-3)-Gal-beta-(1-3)-GalNAcOH-(6-1)-GlcNAc-beta-(4-1)-[Fuc-alpha-(1-2)]-Gal-beta (1 %, O antigen-, A antigen- and B antigen-specific).
Cellular Location:	Cell membrane. Appears to be colocalized with SLC4A1.
Database Links:	Entrez Gene: 2993?Human Omim: 111300?Human SwissProt: P02724?Human Unigene: 434973?Human
Synonyms:	AI853584 Antibody Blood group--MN locus Antibody CD235a Antibody CD_antigen=CD235a Antibody GLPA_HUMAN Antibody Glycophorin A Antibody Glycophorin A (MNS blood group) Antibody Glycophorin A, included Antibody Glycophorin-A Antibody GlycophorinA Antibody GPA Antibody GPErik Antibody GpMiIII Antibody GPSAT Antibody GYPA Antibody GYPA, included Antibody HGpMiIII Antibody HGpMiV Antibody HGpMiX Antibody HGpMiXI Antibody HGpSta(C) Antibody MN Antibody MN sialoglycoprotein Antibody MNS Antibody PAS-2 Antibody PAS2 Antibody Sialoglycoprotein alpha Antibody
Information:	Target information shown above is from the UniProt Consortium.