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Anti-CD229 Antibody

品牌：Antibodies

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規(guī)格：100T

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Anti-CD229 Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-CD229 Antibody See all CD229 primary antibodies
Description:	Mouse monoclonal (HLy9.25) antibody to CD229 (APC).
Specificity:	The mouse monoclonal antibody HLy9.25 (also known as HLy9.1.25) recognizes CD229 / Ly9, a 100-120 kDa cell surface glycoprotein expressed on T and B cells.
Applications:	FC, IP, WB, ICC, FUNC
Reactivity:	Human
Immunogen:	CD299-transfected 300.19 pre-B cell line.
Host:	Mouse
Clonality:	Monoclonal
Clone:	HLy9.25
Isotype:	IgG1
Conjugate:	APC
Purification:	Size exclusion chromatography.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline with 15mM Sodium Azide.
Storage:	Store in the dark at 2-8°C. Avoid prolonged exposure to light.

Target

Function:	Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. May participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction. Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (PubMed:22184727). Promotes recruitment of RORC to the IL-17 promoter (PubMed:22989874). May be involved in the maintenance of peripheral cell tolerance by serving as a negative regulator of the immune response. May disable autoantibody responses and inhibit IFN-gamma secretion by CD4(+) T-cells. May negatively regulate the size of thymic innate CD8(+) T-cells and the development of invariant natural killer T (iNKT) cells (By similarity).
Tissue Specificity:	Increased surface expression on T-cells of systemic lupus erythematosus (SLE) patients.
Cellular Location:	Membrane. Cell membrane.
Database Links:	Entrez Gene: 4063?Human Omim: 600684?Human SwissProt: Q9HBG7?Human Unigene: 403857?Human
Synonyms:	CD229 Antibody Cell surface molecule Ly-9 Antibody Cell surface molecule Ly9 Antibody hly9 Antibody LY 9 Antibody Ly9 Antibody LY9_HUMAN Antibody Lymphocyte antigen 9 Antibody mLY9 Antibody Signaling lymphocytic activation molecule 3 Antibody SLAM family member 3 Antibody SLAMF3 Antibody T lymphocyte surface antigen Ly9 precursor Antibody T-lymphocyte surface antigen Ly-9 Antibody
Information:	Target information shown above is from the UniProt Consortium.