The mouse monoclonal antibody 5E8 recognizes CD193 (chemokine receptor 3), an approximately 41 kDa protein expressed above all in eosinophils and basophils.
Applications:
FC
Reactivity:
Human
Host:
Mouse
Clonality:
Monoclonal
Clone:
5E8
Isotype:
IgG2b
Conjugate:
Unconjugated
Purification:
Protein A chromatography.
Concentration:
1 mg/ml
Purity:
> 95% (by SDS-PAGE)
Product Form:
Liquid
Formulation:
Supplied in Phosphate Buffered Saline, pH 7.4, with 15mM Sodium Azide.
Storage:
Store at 2-8°C.
Target
Function:
Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.
Tissue Specificity:
In eosinophils as well as trace amounts in neutrophils and monocytes.
Sequence Similarities:
Belongs to the G-protein coupled receptor 1 family.
Cellular Location:
Cell membrane.
Database Links:
Entrez Gene: 1232?Human
Omim: 601268?Human
SwissProt: P51677?Human
Unigene: 506190?Human
Synonyms:
B chemokine receptor Antibody
b-chemokine receptor Antibody
C C chemokine receptor type 3 Antibody
C C CKR 3 Antibody
C-C chemokine receptor type 3 Antibody
C-C CKR-3 Antibody
CC chemokine receptor 3 Antibody
CC chemokine receptor type 3 Antibody
CC CKR 3 Antibody
CC R3 Antibody
CC-CKR-3 Antibody
CCCKR3 Antibody
CCR 3 Antibody
CCR-3 Antibody
CCR3 Antibody
CCR3_HUMAN Antibody
CD 193 Antibody
CD193 Antibody
CD193 antigen Antibody
Chemokine (C C motif) receptor 3 Antibody
chemokine (C-C motif) receptor 3 Antibody
Chemokine (CC) receptor 1 like 2 Antibody
Chemokine CC motif receptor 3 Antibody
Chemokine receptor 3 Antibody
CK R3 Antibody
CKR 3 Antibody
CKR3 Antibody
CMKB R3 Antibody
CMKBR 3 Antibody
CMKBR1L2 Antibody
CMKBR3 Antibody
Eosinophil CC chemokine receptor 3 Antibody
Eosinophil eotaxin receptor Antibody
Eotaxin receptor Antibody
Macrophage inflammatory protein 1 alpha receptor like 2 Antibody
MGC102841 Antibody
MIP1 Alpha RL2 Antibody
Information:
Target information shown above is from the UniProt Consortium.