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Anti-CCR6 Antibody

品牌：Antibodies

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規(guī)格：100μl

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Anti-CCR6 Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-CCR6 Antibody See all CCR6 primary antibodies
Description:	Rabbit polyclonal antibody to CCR6
Specificity:	The antibody detects endogenous levels of total CCR6 protein.
Applications:	WB, IHC
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to residues near the N terminal of human chemokine (C-C motif) receptor 6
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	2.9mg / ml
Formulation:	Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage:	Store at -20?C

Target

Function:	Receptor for the C-C type chemokine CCL20 (PubMed:9169459). Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels (PubMed:20068036). Although CCL20 is its major ligand it can also act as a receptor for non-chemokine ligands such as beta-defensins (PubMed:25585877). Binds to defensin DEFB1 leading to increase in intracellular calcium ions and cAMP levels. Its binding to DEFB1 is essential for the function of DEFB1 in regulating sperm motility and bactericidal activity (PubMed:25122636). Binds to defensins DEFB4 and DEFB4A/B and mediates their chemotactic effects (PubMed:20068036). The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/ memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases. CCR6-mediated signals are essential for immune responses to microbes in the intestinal mucosa and in the modulation of inflammatory responses initiated by tissue insult and trauma (PubMed:21376174). CCR6 is essential for the recruitment of both the proinflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for the normal migration of Th17 cells in Peyers-patches and other related tissue sites of the intestine and plays a role in regulating effector T-cell balance and distribution in inflamed intestine. Plays an important role in the coordination of early thymocyte precursor migration events important for normal subsequent thymocyte precursor development, but is not required for the formation of normal thymic natural regulatory T-cells (nTregs). Required for optimal differentiation of DN2 and DN3 thymocyte precursors. Essential for B-cell localization in the subepithelial dome of Peyers-patches and for efficient B-cell isotype switching to IgA in the Peyers-patches. Essential for appropriate anatomical distribution of memory B-cells in the spleen and for the secondary recall response of memory B-cells (By similarity). Positively regulates sperm motility and chemotaxis via its binding to CCL20 (PubMed:23765988).
Tissue Specificity:	Sperm. Mainly localized in the tail and in the postacrosomal region but is also found in the midpiece and basal region in a small percentage of sperm cells. Reduced levels found in the sperms of asthenozoospermia and leukocytospermia patients (at protein level). Spleen, lymph nodes, appendix, and fetal liver. Expressed in lymphocytes, T-cells and B-cells but not in natural killer cells, monocytes or granulocytes.
Sequence Similarities:	Belongs to the G-protein coupled receptor 1 family.
Cellular Location:	Cell membrane. Cell surface.
Database Links:	Entrez Gene: 1235?Human Omim: 601835?Human SwissProt: P51684?Human Unigene: 46468?Human
Synonyms:	BN 1 Antibody BN1 Antibody C C chemokine receptor type 6 Antibody C C CKR 6 Antibody C-C chemokine receptor type 6 Antibody C-C CKR-6 Antibody CC chemokine receptor type 6 Antibody CC CKR 6 Antibody CC R6 Antibody CC-CKR-6 Antibody CCCKR6 Antibody CCR 6 Antibody CCR-6 Antibody Ccr6 Antibody CCR6/CD196 Antibody CCR6_HUMAN Antibody CD 196 Antibody CD196 Antibody CD196 antigen Antibody Chemokine (C C motif) receptor 6 Antibody Chemokine (C C) receptor 6 Antibody Chemokine (CC motif) receptor 6 Antibody Chemokine (CC) receptor 6 Antibody Chemokine receptor 6 Antibody Chemokine receptor like 3 Antibody Chemokine receptor-like 3 Antibody CKR 6 Antibody CKR L3 Antibody CKR-L3 Antibody CKR6 Antibody CKRL3 Antibody CMKBR 6 Antibody CMKBR6 Antibody DCR 2 Antibody DCR2 Antibody DRY 6 Antibody DRY6 Antibody G protein coupled receptor 29 Antibody G-protein coupled receptor 29 Antibody GPR 29 Antibody GPR CY4 Antibody GPR-CY4 Antibody GPR29 Antibody GPRCY 4 Antibody GPRCY4 Antibody LARC receptor Antibody Seven transmembrane receptor lymphocyte 22 Antibody STRL 22 Antibody STRL22 Antibody
Information:	Target information shown above is from the UniProt Consortium.