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Anti-CBP20 (R21) Antibody

品牌：Antibodies

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Anti-CBP20 (R21) Antibody

商品詳情參考文獻相關(guān)資料

Overview

Name:	Anti-CBP20 (R21) Antibody See all CBP20 primary antibodies
Description:	Rabbit polyclonal antibody to CBP20 (R21)
Specificity:	CBP20 (R21) pAb detects endogenous levels of CBP20 protein.
Applications:	WB, IHC, IF
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids N-terminus of Human CBP20.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 18 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC) via its interaction with UPF1, promoting the interaction between UPF1 and UPF2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of PARN, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, NCBP2/CBP20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires NCBP1/CBP80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus (PubMed:26382858).
Sequence Similarities:	Belongs to the RRM NCBP2 family.
Cellular Location:	Nucleus. Cytoplasm.
Database Links:	Entrez Gene: 22916?Human Entrez Gene: 68092?Mouse Entrez Gene: 288040?Rat Omim: 605133?Human SwissProt: P52298?Human SwissProt: Q9CQ49?Mouse SwissProt: B1WC40?Rat Unigene: 591671?Human
Synonyms:	20 kDa nuclear cap binding protein Antibody CBC2 Antibody CBP20 Antibody Cell proliferation inducing gene 55 protein Antibody NCBP 2 Antibody NCBP 20 kDa subunit Antibody NCBP interacting protein 1 Antibody NCBP2 Antibody NIP1 Antibody Nuclear cap binding protein subunit 2 Antibody PIG55 Antibody
Information:	Target information shown above is from the UniProt Consortium.