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Anti-CBL Antibody

品牌：Antibodies

貨號(hào)：

規(guī)格：100μg

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Anti-CBL Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-CBL Antibody See all CBL primary antibodies
Description:	Goat polyclonal antibody to CBL.
Applications:	ELISA, WB
Reactivity:	Mouse
Immunogen:	Synthetic peptide corresponding to Human CBL (C terminal).
Sequence:	C-REFVSISSPAHVAT
Host:	Goat
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	100 μg at 0.5 mg/ml.
Product Form:	Liquid
Formulation:	Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation. Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis. Essential for osteoclastic bone resorption. The 'Tyr-737' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3.
Post-Translational Modification:	Phosphorylated on tyrosine residues by ALK, EGFR, FGR, INSR, SYK, FYN and ZAP70. Phosphorylated on several tyrosine residues by constitutively activated FGFR3. Phosphorylated on tyrosine residues by activated PDGFRA and PDGFRB (By similarity). Phosphorylated on tyrosine residues in response to CSF1R, FLT1 and KIT signaling. Phosphorylated on tyrosine residues by HCK.
Cellular Location:	Cytoplasm. Cell membrane. Colocalizes with FGFR2 in lipid rafts at the cell membrane.
Database Links:	Entrez Gene: 12402?Mouse SwissProt: P22682?Mouse Unigene: 266871?Mouse
Synonyms:	4732447J05Rik Antibody C CBL Antibody Cas Br M (murine) ecotropic retroviral transforming sequence Antibody Casitas B lineage lymphoma proto oncogene Antibody Casitas B-lineage lymphoma proto-oncogene Antibody CBL Antibody CBL 2 Antibody CBL2 Antibody CBL_HUMAN Antibody E3 ubiquitin protein ligase CBL Antibody E3 ubiquitin-protein ligase CBL Antibody Oncogene CBL2 Antibody Proto oncogene c CBL Antibody Proto-oncogene c-CBL Antibody RGD1561386 Antibody RING finger protein 55 Antibody RNF55 Antibody Signal transduction protein CBL Antibody
Information:	Target information shown above is from the UniProt Consortium.