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Anti-CBFA1 Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-CBFA1 Antibody

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Overview

Name:	Anti-CBFA1 Antibody See all CBFA1 primary antibodies
Description:	Rabbit polyclonal antibody to CBFA1
Specificity:	The antibody detects endogenous level of total CBFA1 protein.
Applications:	E, WB, IHC
Reactivity:	Human, Mouse
Immunogen:	Synthetic peptide corresponding to a region derived from 320-336 amino acids of Human Core-binding factor subunit alpha-1
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Formulation:	Supplied at 0.8mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, 0.05% sodium azide and 50% glycerol.
Storage:	Store at -20?C / 1 year

Target

Function:	Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. Inhibits KAT6B-dependent transcriptional activation (By similarity). In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).
Tissue Specificity:	Found in thymus and testis, T-cell lines but not in B-cell lines. Isoform 2 is exclusively found in bone, particularly in osteoblasts; isoforms 3 and 4 are expressed in T-cell lines; isoforms 5, 6, 7, 8 and 9 can be found in osteoblasts and osteosarcoma cell lines.
Post-Translational Modification:	Phosphorylated; probably by MAP kinases (MAPK). Phosphorylation by HIPK3 is required for the SPEN/MINT and FGF2 transactivation during osteoblastic differentiation. Phosphorylation at Ser-537 by CDK1 promotes endothelial cell proliferation required for tumor angiogenesis probably by facilitating cell cycle progression (By similarity).
Cellular Location:	Nucleus.
Database Links:	Entrez Gene: 860?Human Entrez Gene: 12393?Mouse Omim: 600211?Human SwissProt: Q13950?Human SwissProt: Q08775?Mouse Unigene: 535845?Human Unigene: 391013?Mouse Unigene: 391017?Mouse
Synonyms:	Acute myeloid leukemia 3 protein Antibody Alpha subunit 1 Antibody AML3 Antibody CBF alpha 1 Antibody CBF-alpha-1 Antibody CBFA1 Antibody CCD Antibody CCD1 Antibody Cleidocranial dysplasia 1 Antibody Core binding factor Antibody Core binding factor runt domain alpha subunit 1 Antibody Core binding factor subunit alpha 1 Antibody Core-binding factor subunit alpha-1 Antibody MGC120022 Antibody MGC120023 Antibody Oncogene AML 3 Antibody Oncogene AML-3 Antibody OSF 2 Antibody OSF-2 Antibody OSF2 Antibody Osteoblast specific transcription factor 2 Antibody Osteoblast-specific transcription factor 2 Antibody OTTHUMP00000016533 Antibody PEA2 alpha A Antibody PEA2-alpha A Antibody PEA2aA Antibody PEBP2 alpha A Antibody PEBP2-alpha A Antibody PEBP2A1 Antibody PEBP2A2 Antibody PEBP2aA Antibody PEBP2aA1 Antibody Polyomavirus enhancer binding protein 2 alpha A subunit Antibody Polyomavirus enhancer-binding protein 2 alpha A subunit Antibody Runt domain Antibody Runt related transcription factor 2 Antibody Runt-related transcription factor 2 Antibody RUNX2 Antibody RUNX2_HUMAN Antibody SL3 3 enhancer factor 1 alpha A subunit Antibody SL3-3 enhancer factor 1 alpha A subunit Antibody SL3/AKV core binding factor alpha A subunit Antibody SL3/AKV core-binding factor alpha A subunit Antibody
Information:	Target information shown above is from the UniProt Consortium.