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Anti-Caspase-14 Antibody

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Anti-Caspase-14 Antibody

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Overview

Name:	Anti-Caspase-14 Antibody See all Caspase-14 primary antibodies
Description:	Rabbit polyclonal antibody to Caspase-14
Applications:	E, WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Raised against a 16 amino acid peptide from near the carboxy terminus of human caspase-14.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Affinity chromatography purified via peptide column
Formulation:	Supplied in PBS containing 0.02% sodium azide.
Storage:	Can be stored at -20?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target

Function:	Non-apoptotic caspase which is involved in epidermal differentiation. Seems to play a role in keratinocyte differentiation and is required for cornification (PubMed:18156206). Regulates maturation of the epidermis by proteolytically processing filaggrin (PubMed:21654840). In vitro is equally active on the synthetic caspase substrates WEHD-ACF and IETD-AFC. Involved in processing of prosaposin in the epidermis (PubMed:24872419). May be involved in retinal pigment epithelium cell barrier function (By similarity).
Tissue Specificity:	Embryo, *** liver and less in * brain and kidney. Expressed in differentiating keratinocytes of embryonic skin (at protein level). Expressed in keratinocytes of *** skin suprabasal layers (at protein level).
Sequence Similarities:	Belongs to the peptidase C14A family.
Post-Translational Modification:	Maturation by proteolytic processing appears to be a two-step process. The precursor is processed by KLK7 to yield the p20/p8 intermediate form which acts the precursor to yield the p17/p10 mature form (By similarity). Initially it was reported that cleavage by granzyme B, caspase-8 and -10 generates the two active subunits, however the physiological relevance has not been established (PubMed:9823333).
Cellular Location:	Cytoplasm. Nucleus.
Database Links:	Entrez Gene: 23581?Human Entrez Gene: 12365?Mouse Entrez Gene: 299587?Rat Omim: 605848?Human SwissProt: P31944?Human SwissProt: O89094?Mouse Unigene: 466057?Human Unigene: 20940?Mouse Unigene: 228179?Rat
Synonyms:	Apoptosis related cysteine protease Antibody CASP 14 Antibody CASP-14 Antibody CASP14 Antibody Caspase 14 apoptosis related cysteine protease Antibody Caspase 14 precursor Antibody Caspase-14 Antibody Caspase-14 subunit p10 Antibody Caspase14 Antibody CASPE_HUMAN Antibody MGC119078 Antibody MGC119079 Antibody MICE Antibody Mini ICE Antibody
Information:	Target information shown above is from the UniProt Consortium.