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Anti-Caspase 4 (E124) Antibody

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Anti-Caspase 4 (E124) Antibody

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Overview

Name:	Anti-Caspase 4 (E124) Antibody See all Caspase 4 primary antibodies
Description:	Rabbit polyclonal antibody to Caspase 4 (E124)
Specificity:	Caspase-4 (E124) pAb detects endogenous levels of Caspase-4 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 100-150 of Human Caspase 4.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 45 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Inflammatory caspase (PubMed:7797510, PubMed:23516580, PubMed:25119034). Essential effector of NLRP3 inflammasome-dependent CASP1 activation and IL1B and IL18 secretion in response to non-canonical activators, such as UVB radiation, cholera enterotoxin subunit B and cytosolic LPS (PubMed:22246630, PubMed:26174085, PubMed:26173988, PubMed:26508369, PubMed:25964352). Independently of NLRP3 inflammasome and CASP1, promotes pyroptosis, through GSDMD cleavage and activation, and IL1A, IL18 and HMGB1 release in response to non-canonical inflammasome activators (PubMed:24879791, PubMed:25964352). Plays a crucial role in the restriction of Salmonella typhimurium replication in colonic epithelial cells during infection (PubMed:25121752). In later stages of the infection, LPS from cytosolic Salmonella triggers CASP4 activation, which ultimately results in pyroptosis of infected cells and their extrusion into the gut lumen, as well as in IL18 secretion. Pyroptosis limits bacterial replication, while cytokine secretion promotes the recruitment and activation of immune cells and triggers mucosal inflammation. Involved in LPS-induced IL6 secretion; this activity may not require caspase enzymatic activity (PubMed:26508369). Involved in cell death induced by endoplasmic reticulum stress and by treatment with cytotoxic APP peptides found Alzheimer's patient brains (PubMed:15123740, PubMed:22246630, PubMed:23661706). Activated by direct binding to LPS without the need of an upstream sensor (PubMed:25119034). Does not directly process IL1B (PubMed:7743998, PubMed:7797592, PubMed:7797510).
Tissue Specificity:	Widely expressed, including in keratinocytes and colonic and small intestinal epithelial cells (at protein level). Not detected in brain.
Sequence Similarities:	Belongs to the peptidase C14A family.
Post-Translational Modification:	In response to activation signals, including endoplasmic reticulum stress or treatment with amyloid beta A4 protein fragments (such as beta-amyloid protein 40), undergoes autoproteolytic cleavage.
Cellular Location:	Cytoplasm > Cytosol. Endoplasmic reticulum membrane. Mitochondrion. Inflammasome. Secreted. Predominantly localizes to the endoplasmic reticulum (ER). Association with the ER membrane requires TMEM214 (PubMed:15123740). Released in the extracellular milieu by keratinocytes following UVB irradiation (PubMed:22246630).
Database Links:	Entrez Gene: 837?Human Entrez Gene: 12363?Mouse Omim: 602664?Human SwissProt: P49662?Human SwissProt: P70343?Mouse Unigene: 138378?Human Unigene: 1569?Mouse
Synonyms:	Apoptotic cysteine protease Mih1/TX Antibody CASP-4 Antibody CASP4 Antibody CASP4_HUMAN Antibody Caspase 4 Antibody Caspase 4 apoptosis related cysteine peptidase Antibody Caspase-4 subunit 2 Antibody Caspase4 Antibody ICE(rel)-II Antibody ICE(rel)II Antibody ICEREL II Antibody ICERELII Antibody ICH2 Antibody Mih1/TX Antibody Protease ICH-2 Antibody Protease TX Antibody TX Antibody
Information:	Target information shown above is from the UniProt Consortium.