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Anti-CaMKIIα (phospho-T286) Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-CaMKIIα (phospho-T286) Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Name:	Anti-CaMKIIα (phospho-T286) Antibody See all CaMKIIα primary antibodies
Description:	Rabbit polyclonal antibody to CaMKIIα (phospho-T286)
Specificity:	p-CaMK2-a (T286) pAb detects endogenous levels of CaMK2-a protein only when phosphorylated at Thr286.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic phosphopeptide derived from human CaMKIIα around the phosphorylation site of Threonine 286.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 54 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Function:	CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity). Phosphorylates transcription factor FOXO3 on 'Ser-298' (PubMed:23805378). Activates FOXO3 transcriptional activity (By similarity).
Sequence Similarities:	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Cellular Location:	Cell junction > Synapse > Presynaptic cell membrane. Cell junction > Synapse. Postsynaptic lipid rafts.