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Anti-CaMKII (Phospho-Thr286) Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-CaMKII (Phospho-Thr286) Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-CaMKII (Phospho-Thr286) Antibody See all CaMKII primary antibodies
Description:	Rabbit polyclonal antibody to CaMKII (Phospho-Thr286)
Specificity:	The antibody detects endogenous level of CaMKII only when phosphorylated at threonine 286.
Applications:	WB
Dilutions:	Western blotting: 1:500~1:1000
Reactivity:	Human, Mouse, Rat
Immunogen:	Peptide sequence around phosphorylation site of threonine 286 (Q-E-T(p)-V-D) derived from Human CaMKII.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Concentration:	1.0mg / ml
Predicted MW:	50kd
Formulation:	Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Target

Function:	CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity). Phosphorylates transcription factor FOXO3 on 'Ser-298' (PubMed:23805378). Activates FOXO3 transcriptional activity (By similarity).
Sequence Similarities:	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Cellular Location:	Cell junction > Synapse > Presynaptic cell membrane. Cell junction > Synapse. Postsynaptic lipid rafts.
Database Links:	Entrez Gene: 815?Human Entrez Gene: 816?Human Entrez Gene: 817?Human Entrez Gene: 818?Human Entrez Gene: 108058?Mouse Entrez Gene: 12322?Mouse Entrez Gene: 12323?Mouse Entrez Gene: 12325?Mouse Entrez Gene: 171140?Rat Entrez Gene: 24245?Rat Entrez Gene: 24246?Rat Entrez Gene: 25400?Rat Omim: 114078?Human SwissProt: Q13554?Human SwissProt: Q13555?Human SwissProt: Q13557?Human SwissProt: Q9UQM7?Human SwissProt: P11798?Mouse SwissProt: P28652?Mouse SwissProt: Q6PHZ2?Mouse SwissProt: Q923T9?Mouse SwissProt: P08413?Rat SwissProt: P11275?Rat SwissProt: P11730?Rat SwissProt: P15791?Rat Unigene: 725992?Human Unigene: 131530?Mouse Unigene: 107499?Rat
Synonyms:	Calcium/calmodulin dependent protein kinase II alpha Antibody Calcium/calmodulin dependent protein kinase II beta Antibody Calcium/calmodulin dependent protein kinase II delta Antibody Calcium/calmodulin dependent protein kinase II gamma Antibody Calcium/calmodulin-dependent protein kinase type II subunit alpha Antibody CaM kinase II Antibody CaM kinase II alpha Antibody CaM kinase II beta Antibody CaM kinase II delta Antibody CaM kinase II gamma Antibody CaM kinase II subunit alpha Antibody CaMK-II subunit alpha Antibody CAMK2 Antibody Camk2a Antibody CAMK2B Antibody CAMK2D Antibody CAMK2G Antibody CAMKA Antibody CaMKII Antibody KCC2A_HUMAN Antibody
Information:	Target information shown above is from the UniProt Consortium.