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Anti-CaMK2α / β / δ (Phospho-Thr305) Antibody

品牌：Antibodies

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規(guī)格：50μl

貨期：

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Anti-CaMK2α / β / δ (Phospho-Thr305) Antibody

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Name:	Anti-CaMK2α / β / δ (Phospho-Thr305) Antibody See all CaMK2α primary antibodies
Description:	Rabbit polyclonal antibody to CaMK2α / β / δ (Phospho-Thr305)
Specificity:	The antibody detects endogenous levels of CaMKII only when phosphorylated at threonine 305.
Applications:	WB, IHC
Dilutions:	Western blotting: 1:500~1:1000Immunohistochemistry: 1:50~1:100
Reactivity:	Human
Immunogen:	Peptide sequence around phosphorylation site of threonine 305 (I-L-T(p)-T-M) derived from Human CaMK2α / β / δ.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Concentration:	1.0mg / ml
Formulation:	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20?C / 1 year

Function:	CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity). Phosphorylates transcription factor FOXO3 on 'Ser-298' (PubMed:23805378). Activates FOXO3 transcriptional activity (By similarity).
Sequence Similarities:	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Cellular Location:	Cell junction > Synapse > Presynaptic cell membrane. Cell junction > Synapse. Postsynaptic lipid rafts.