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Anti-Cables1 (K588) Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-Cables1 (K588) Antibody

商品詳情參考文獻相關(guān)資料

Overview

Name:	Anti-Cables1 (K588) Antibody See all Cables1 primary antibodies
Description:	Rabbit polyclonal antibody to Cables1 (K588)
Specificity:	Cables1 (K588) pAb detects endogenous levels of Cables1 protein.
Applications:	WB, IHC, IF
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 550-600 of Human Cables1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 67 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity).
Tissue Specificity:	Expressed in breast, pancreas, colon, head and neck (at protein level). Strongly decreased in more than half of cases of atypical endometrial hyperplasia and in more than 90% of endometrial cancers.
Sequence Similarities:	Belongs to the cyclin family.
Post-Translational Modification:	Phosphorylated on Ser-313 by CCNE1/CDK3. Phosphorylated on serine/threonine residues by CDK5 and on tyrosine residues by ABL1. Also phosphorylated in vitro by CCNA1/CDK2, CCNE1/CDK2, CCNA1/CDK3 and CCNE1/CDK3 (By similarity).
Cellular Location:	Nucleus. Cytoplasm. Located in the cell body and proximal region of the developing axonal shaft of immature neurons. Located in axonal growth cone, but not in the distal part of the axon shaft or in dendritic growth cone of mature neurons (By similarity).
Database Links:	Entrez Gene: 91768?Human Entrez Gene: 63955?Mouse Entrez Gene: 307585?Rat Omim: 609194?Human SwissProt: Q8TDN4?Human SwissProt: Q9ESJ1?Mouse Unigene: 11108?Human Unigene: 40717?Mouse Unigene: 43941?Rat
Synonyms:	CABL1_HUMAN Antibody CABLES Antibody CABLES1 Antibody Cdk5 and Abl enzyme substrate 1 Antibody CDK5 and ABL1 enzyme substrate 1 Antibody FLJ35924 Antibody HsT2563 Antibody IK3 1 Antibody Ik3-1 Antibody Interactor with CDK3 1 Antibody
Information:	Target information shown above is from the UniProt Consortium.