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Anti-C1q-C (Q119) Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-C1q-C (Q119) Antibody

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Name:	Anti-C1q-C (Q119) Antibody See all C1qC primary antibodies
Description:	Rabbit polyclonal antibody to C1q-C (Q119)
Specificity:	C1q-C (Q119) pAb detects endogenous levels of C1q-C protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 81-130 of Human C1q-C.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 30 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Function:	C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
Involvement in Disease:	Complement component C1q deficiency: A disorder caused by impaired activation of the complement classical pathway. It generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.
Post-Translational Modification:	O-linked glycans consist of Glc-Gal disaccharides bound to the oxygen atom of post-translationally added hydroxyl groups.
Cellular Location:	Secreted.
Database Links:	Entrez Gene: 714?Human Entrez Gene: 12262?Mouse Entrez Gene: 362634?Rat Omim: 120575?Human SwissProt: P02747?Human SwissProt: Q02105?Mouse SwissProt: P31722?Rat Unigene: 467753?Human Unigene: 439732?Mouse Unigene: 2393?Rat
Synonyms:	AI385742 Antibody C1Q C Antibody C1QC Antibody C1QC_HUMAN Antibody C1QG Antibody Complement C1q subcomponent subunit C Antibody Complement component 1, q subcomponent, C chain Antibody complement component 1, q subcomponent, gamma polypeptide Antibody
Information:	Target information shown above is from the UniProt Consortium.