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Anti-C/EBP-β (phospho-T235/188) Antibody

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Anti-C/EBP-β (phospho-T235/188) Antibody

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Anti-C/EBP-β (phospho-T235/188) Antibody

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Overview

Name:	Anti-C/EBP-β (phospho-T235/188) Antibody See all C primary antibodies
Description:	Rabbit polyclonal antibody to C/EBP-β (phospho-T235/188)
Specificity:	p-C/EBP-β (T235/188) pAb detects endogenous levels of human LAP only when phosphorylated at Thr235, mouse and rat LAP only when phosphorylated at Thr188, and LIP only when phosphorylated at Thr37.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic phosphopeptide derived from human C/EBP-β around the phosphorylation site of Threonine 235.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 19, 36, 38 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:1741402, PubMed:9374525, PubMed:12048245, PubMed:18647749). Plays also a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant functions with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage. Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Plays also a role in intracellular bacteria killing (By similarity). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (PubMed:20829347). Essential for female reproduction because of a critical role in ovarian follicle development (By similarity). Restricts osteoclastogenesis (By similarity).
Tissue Specificity:	Expressed at low levels in the lung, kidney and spleen.
Sequence Similarities:	Belongs to the bZIP family. C/EBP subfamily.
Post-Translational Modification:	Methylated. Methylation at Arg-3 by CARM1 and at Lys-43 by EHMT2 inhibit transactivation activity. Methylation is probably inhibited by phosphorylation at Thr-235.
Cellular Location:	Nucleus. Cytoplasm. Translocates to the nucleus when phosphorylated at Ser-288. In T-cells when sumoylated drawn to pericentric heterochromatin thereby allowing proliferation (By similarity).
Synonyms:	C Antibody Capsid protein Antibody core Antibody Core and e antigen Antibody Core antigen Antibody Core protein Antibody HBc Antibody HBcAg Antibody HBVgp4 Antibody Hepatitis B core antigen Antibody Hepatitis B Virus Core Antigen Antibody p21.5 Antibody precore/core protein Antibody
Information:	Target information shown above is from the UniProt Consortium.