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Anti-c-TAK1 (P8) Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-c-TAK1 (P8) Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-c-TAK1 (P8) Antibody See all c-TAK1 primary antibodies
Description:	Rabbit polyclonal antibody to c-TAK1 (P8)
Specificity:	c-TAK1 (P8) pAb detects endogenous levels of C-TAK1 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to the N-terminal of Human c-TAK1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 87 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Involved in the specific phosphorylation of microtubule-associated proteins for tau, MAP2 and MAP4. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus.
Tissue Specificity:	Ubiquitous.
Sequence Similarities:	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
Post-Translational Modification:	Phosphorylated at Thr-211 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Phosphorylation at Thr-564 by PRKCZ/aPKC inhibits the kinase activity.
Cellular Location:	Cell membrane.
Database Links:	Entrez Gene: 4140?Human Entrez Gene: 17169?Mouse Omim: 602678?Human SwissProt: P27448?Human SwissProt: Q03141?Mouse Unigene: 35828?Human Unigene: 260504?Mouse Unigene: 408955?Mouse Unigene: 420865?Mouse
Synonyms:	C-TAK1 Antibody Cdc25C associated protein kinase 1 Antibody Cdc25C-associated protein kinase 1 Antibody cTAK1 Antibody ELKL motif kinase 2 Antibody EMK-2 Antibody Emk2 Antibody ETK 1 Antibody KIAA4230 Antibody KP78 Antibody MAP microtubule affinity regulating kinase 3 Antibody MAP/microtubule affinity-regulating kinase 3 Antibody Mark3 Antibody MARK3_HUMAN Antibody Par 1a Antibody PAR1A Antibody Protein kinase STK10 Antibody Ser/Thr protein kinase PAR-1 Antibody Serine threonine protein kinase p78 Antibody Serine/threonine-protein kinase p78 Antibody SerThr protein kinase PAR 1 Antibody
Information:	Target information shown above is from the UniProt Consortium.