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Anti-c-Jun (phospho-Y170) Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-c-Jun (phospho-Y170) Antibody

商品詳情參考文獻相關(guān)資料

Overview

Name:	Anti-c-Jun (phospho-Y170) Antibody See all c-Jun primary antibodies
Description:	Rabbit polyclonal antibody to c-Jun (phospho-Y170)
Specificity:	p-c-Jun (Y170) pAb detects endogenous levels of c-Jun protein only when phosphorylated at Tyr170.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic phosphopeptide derived from human c-Jun around the phosphorylation site of Tyrosine 170.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 43, 48 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306).
Sequence Similarities:	Belongs to the bZIP family. Jun subfamily.
Post-Translational Modification:	Ubiquitinated by the SCF(FBXW7), leading to its degradation. Ubiquitination takes place following phosphorylation, that promotes interaction with FBXW7.
Cellular Location:	Nucleus.
Database Links:	Entrez Gene: 3725?Human Entrez Gene: 16476?Mouse Entrez Gene: 24516?Rat Omim: 165160?Human SwissProt: P05412?Human SwissProt: P05627?Mouse SwissProt: P17325?Rat Unigene: 696684?Human Unigene: 275071?Mouse Unigene: 93714?Rat
Synonyms:	Activator protein 1 Antibody AP 1 Antibody AP1 Antibody c-Jun Antibody cJun Antibody Enhancer Binding Protein AP1 Antibody JUN Antibody Jun Activation Domain Binding Protein Antibody Jun oncogene Antibody JUN protein Antibody Jun proto oncogene Antibody JUNC Antibody JUN_HUMAN Antibody Oncogene JUN Antibody p39 Antibody Proto oncogene c jun Antibody Proto oncogene cJun Antibody Proto-oncogene c-jun Antibody Transcription Factor AP 1 Antibody Transcription factor AP-1 Antibody Transcription Factor AP1 Antibody V jun avian sarcoma virus 17 oncogene homolog Antibody V jun sarcoma virus 17 oncogene homolog Antibody V jun sarcoma virus 17 oncogene homolog (avian) Antibody V-jun avian sarcoma virus 17 oncogene homolog Antibody vJun Avian Sarcoma Virus 17 Oncogene Homolog Antibody
Information:	Target information shown above is from the UniProt Consortium.