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Anti-c-Jun (Phospho-Ser243) Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-c-Jun (Phospho-Ser243) Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-c-Jun (Phospho-Ser243) Antibody See all c-Jun primary antibodies
Description:	Rabbit polyclonal antibody to c-Jun (Phospho-Ser243)
Specificity:	The antibody detects endogenous level of c-Jun only when phosphorylated at serine 243.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Peptide sequence around phosphorylation site of serine 243 (P-L-S(p)-P-I) derived from Human c-Jun.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Concentration:	1.0mg / ml
Formulation:	Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Target

Function:	Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306).
Sequence Similarities:	Belongs to the bZIP family. Jun subfamily.
Post-Translational Modification:	Ubiquitinated by the SCF(FBXW7), leading to its degradation. Ubiquitination takes place following phosphorylation, that promotes interaction with FBXW7.
Cellular Location:	Nucleus.
Database Links:	Entrez Gene: 3725?Human Entrez Gene: 16476?Mouse Entrez Gene: 24516?Rat Omim: 165160?Human SwissProt: P05412?Human SwissProt: P05627?Mouse SwissProt: P17325?Rat Unigene: 696684?Human Unigene: 275071?Mouse Unigene: 93714?Rat
Synonyms:	Activator protein 1 Antibody AP 1 Antibody AP1 Antibody c-Jun Antibody cJun Antibody Enhancer Binding Protein AP1 Antibody JUN Antibody Jun Activation Domain Binding Protein Antibody Jun oncogene Antibody JUN protein Antibody Jun proto oncogene Antibody JUNC Antibody JUN_HUMAN Antibody Oncogene JUN Antibody p39 Antibody Proto oncogene c jun Antibody Proto oncogene cJun Antibody Proto-oncogene c-jun Antibody Transcription Factor AP 1 Antibody Transcription factor AP-1 Antibody Transcription Factor AP1 Antibody V jun avian sarcoma virus 17 oncogene homolog Antibody V jun sarcoma virus 17 oncogene homolog Antibody V jun sarcoma virus 17 oncogene homolog (avian) Antibody V-jun avian sarcoma virus 17 oncogene homolog Antibody vJun Avian Sarcoma Virus 17 Oncogene Homolog Antibody
Information:	Target information shown above is from the UniProt Consortium.