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Anti-BTK (Ab-222) Antibody

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Anti-BTK (Ab-222) Antibody

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Overview

Name:	Anti-BTK (Ab-222) Antibody See all BTK primary antibodies
Description:	Rabbit polyclonal antibody to BTK (Ab-222)
Specificity:	The antibody detects endogenous levels of total BTK protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse
Immunogen:	Synthesized non-phosphopeptide derived from human BTK around the phosphorylation site of tyrosine 222 (A-L-Y(p)-D-Y).
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1.0mg / ml
Formulation:	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20?C

Target

Function:	Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK. BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways. Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway. The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense. Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells. Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation. BTK plays also a critical role in transcription regulation. Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes. BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B. Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR. GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression. ARID3A and NFAT are other transcriptional target of BTK. BTK is required for the formation of functional ARID3A DNA-binding complexes. There is however no evidence that BTK itself binds directly to DNA. BTK has a dual role in the regulation of apoptosis.
Tissue Specificity:	Predominantly expressed in B-lymphocytes.
Involvement in Disease:	X-linked agammaglobulinemia: Humoral immunodeficiency disease which results in developmental defects in the maturation pathway of B-cells. Affected boys have normal levels of pre-B-cells in their bone marrow but virtually no circulating mature B-lymphocytes. This results in a lack of immunoglobulins of all classes and leads to recurrent bacterial infections like otitis, conjunctivitis, dermatitis, sinusitis in the first few years of life, or even some patients present overwhelming sepsis or meningitis, resulting in death in a few hours. Treatment in most cases is by infusion of intravenous immunoglobulin. X-linked hypogammaglobulinemia and isolated growth hormone deficiency: In rare cases XLA is inherited together with isolated growth hormone deficiency (IGHD).
Sequence Similarities:	Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.
Post-Translational Modification:	Following B-cell receptor (BCR) engagement, translocates to the plasma membrane where it gets phosphorylated at Tyr-551 by LYN and SYK. Phosphorylation at Tyr-551 is followed by autophosphorylation of Tyr-223 which may create a docking site for a SH2 containing protein. Phosphorylation at Ser-180 by PRKCB, leads in translocation of BTK back to the cytoplasmic fraction. Phosphorylation at Ser-21 and Ser-115 creates a for PIN1 at these Ser-Pro motifs, and promotes it's recruitment.
Cellular Location:	Cytoplasm. Cell membrane. Nucleus. In steady state, BTK is predominantly cytosolic. Following B-cell receptor (BCR) engagement by antigen, translocates to the plasma membrane through its PH domain. Plasma membrane localization is a critical step in the activation of BTK. A fraction of BTK also shuttles between the nucleus and the cytoplasm, and nuclear export is mediated by the nuclear export receptor CRM1.
Database Links:	Entrez Gene: 695?Human Entrez Gene: 12229?Mouse Omim: 300300?Human SwissProt: Q06187?Human SwissProt: P35991?Mouse Unigene: 159494?Human Unigene: 4475?Mouse
Synonyms:	Agammaglobulinaemia tyrosine kinase Antibody AGMX 1 Antibody AGMX1 Antibody AT Antibody ATK Antibody B cell progenitor kinase Antibody B-cell progenitor kinase Antibody BPK Antibody Bruton agammaglobulinemia tyrosine kinase Antibody Bruton tyrosine kinase Antibody Bruton’s Tyrosine Kinase Antibody BTK Antibody BTK_HUMAN Antibody dominant-negative kinase-deficient Brutons tyrosine kinase Antibody IMD 1 Antibody IMD1 Antibody MGC126261 Antibody MGC126262 Antibody OTTHUMP00000063593 Antibody PSCTK 1 Antibody PSCTK1 Antibody truncated Bruton agammaglobulinemia tyrosine kinase Antibody Tyrosine protein kinase BTK Antibody Tyrosine-protein kinase BTK Antibody tyrosine-protein kinase BTK isoform (lacking exon 14 Antibody XLA Antibody
Information:	Target information shown above is from the UniProt Consortium.