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Anti-BRMS-1 (E43) Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-BRMS-1 (E43) Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Name:	Anti-BRMS-1 (E43) Antibody See all BRMS1 primary antibodies
Description:	Rabbit polyclonal antibody to BRMS-1 (E43)
Specificity:	BRMS-1 (E43) pAb detects endogenous levels of BRMS-1 protein
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 210-58 of Human BRMS-1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 28 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Function:	Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma.
Tissue Specificity:	Expression levels are higher in term placentas than in early placentas. Low levels of expression observed in normal pregnancies and in molar pregnancies.
Sequence Similarities:	Belongs to the BRMS1 family.
Post-Translational Modification:	Ubiquitinated by a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing SPOP, leading to proteasomal degradation.
Cellular Location:	Nucleus. Cytoplasm. Predominantly nuclear.
Database Links:	Entrez Gene: 25855?Human Entrez Gene: 107392?Mouse Entrez Gene: 293668?Rat Omim: 606259?Human SwissProt: Q9HCU9?Human SwissProt: Q99N20?Mouse SwissProt: Q5M7T3?Rat Unigene: 100426?Human Unigene: 2839?Rat
Synonyms:	AV003220 Antibody AW554636 Antibody Breast cancer metastasis suppressor 1 Antibody Breast cancer metastasis-suppressor 1 Antibody BRMS1 Antibody BRMS1_HUMAN Antibody DKFZp564A063 Antibody MGC95128 Antibody
Information:	Target information shown above is from the UniProt Consortium.