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Anti-BPGM Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-BPGM Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-BPGM Antibody See all BPGM primary antibodies
Description:	Rabbit polyclonal antibody to BPGM.
Applications:	WB, IHC
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human BPGM.
Protein Length:	259
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3-bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.1) activity.
Tissue Specificity:	Expressed in red blood cells. Expressed in non-erythroid cells of the placenta; present in the syncytiotrophoblast layer of the placental villi at the feto-maternal interface (at protein level).
Involvement in Disease:	Bisphosphoglycerate mutase deficiency: A disease characterized by hemolytic anemia, splenomegaly, cholelithiasis and cholecystitis.
Sequence Similarities:	Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Post-Translational Modification:	Glycation of Lys-159 in diabetic patients inactivates the enzyme.
Database Links:	Entrez Gene: 669?Human Entrez Gene: 12183?Mouse Entrez Gene: 296973?Rat Omim: 613896?Human SwissProt: P07738?Human SwissProt: P15327?Mouse Unigene: 198365?Human Unigene: 282863?Mouse Unigene: 204528?Rat
Synonyms:	2 Antibody 2,3-bisphosphoglycerate mutase Antibody 2,3-bisphosphoglycerate mutase, erythrocyte Antibody 2,3-bisphosphoglycerate synthase Antibody 2,3-diphosphoglycerate mutase Antibody 3-bisphosphoglycerate mutase Antibody 3-bisphosphoglycerate synthase Antibody 3-diphosphoglycerate mutase Antibody Ab2 098 Antibody AI323730 Antibody AL022789 Antibody Bisphosphoglycerate mutase Antibody BPG dependent PGAM Antibody BPG-dependent PGAM Antibody BPGM Antibody C86192 Antibody DPGM Antibody erythrocyte Antibody Erythrocyte 2,3 bisphosphoglycerate mutase Antibody PMGE_HUMAN Antibody
Information:	Target information shown above is from the UniProt Consortium.