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Anti-BOK (BH3 domain) Antibody

品牌：Antibodies

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規(guī)格：100μl

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Anti-BOK (BH3 domain) Antibody

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Overview

Name:	Anti-BOK (BH3 domain) Antibody See all BOK primary antibodies
Description:	Rabbit polyclonal antibody to BOK (BH3 domain)
Specificity:	The antibody detects endogenous levels of total BOK(BH3 domain) protein.
Applications:	IHC
Reactivity:	Human
Immunogen:	Synthetic peptide of human BCL2-related ovarian killer
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	1.4mg / ml
Formulation:	Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Storage:	Store at -20?C

Target

Function:	Isoform 1: Apoptosis regulator that functions through different apoptotic signaling pathways (PubMed:27076518, PubMed:15102863, PubMed:20673843). Plays a roles as pro-apoptotic protein that positively regulates intrinsic apoptotic process in a BAX- and BAK1-dependent manner or in a BAX- and BAK1-independent manner (PubMed:27076518, PubMed:15102863). In response to endoplasmic reticulum stress promotes mitochondrial apoptosis through downstream BAX/BAK1 activation and positive regulation of PERK-mediated unfolded protein response (By similarity). Activates apoptosis independently of heterodimerization with survival-promoting BCL2 and BCL2L1 through induction of mitochondrial outer membrane permeabilization, in a BAX- and BAK1-independent manner, in response to inhibition of ERAD-proteasome degradation system, resulting in cytochrome c release (PubMed:27076518). In response to DNA damage, mediates intrinsic apoptotic process in a TP53-dependent manner (PubMed:15102863). Plays a role in granulosa cell apoptosis by CASP3 activation (PubMed:20673843). Plays a roles as anti-apoptotic protein during neuronal apototic process, by negatively regulating poly ADP-ribose polymerase-dependent cell death through regulation of neuronal calcium homeostasis and mitochondrial bioenergetics in response to NMDA excitation (By similarity). In addition to its role in apoptosis, may regulate trophoblast cell proliferation during the early stages of placental development, by acting on G1/S transition through regulation of CCNE1 expression (PubMed:19942931). May also play a role as an inducer of autophagy by disrupting interaction between MCL1 and BECN1 (PubMed:24113155).
Tissue Specificity:	Expressed mainly in oocytes; weak expression in granulosa cells of the developing follicles. In ***** human ovaries, expressed in granulosa cells at all follicular stages, but expression in primordial/primary follicles granulosa cell is stronger than in secondary and antral follicles.
Sequence Similarities:	Belongs to the Bcl-2 family.
Post-Translational Modification:	Ubiquitinated by AMFR/gp78 E3 ubiquitin ligase complex; mediates degradation by ubiquitin-proteasome pathway in a VCP/p97-dependent manner; prevents from pro-apoptotic activity; promotes degradation of newly synthesized proteins that are not ITPR1 associated.
Cellular Location:	Mitochondrion membrane. Endoplasmic reticulum membrane. Mitochondrion inner membrane. Cytoplasm. Nucleus. Mitochondrion. Endoplasmic reticulum. Mitochondrion outer membrane. Early endosome membrane. Recycling endosome membrane. Nucleus outer membrane. Golgi apparatus > cis-Golgi network membrane. Golgi apparatus > trans-Golgi network membrane. Membrane. Nuclear and cytoplasmic compartments in the early stages of apoptosis and during apoptosis it associates with mitochondria (PubMed:19942931). In healthy cells, associates loosely with the membrane in a hit-and-run mode. The insertion and accumulation on membranes is enhanced through the activity of death signals, resulting in the integration of the membrane-bound protein into the membrane (PubMed:15868100). The transmembrane domain controls subcellular localization; constitutes a tail-anchor. Localizes in early and late endosome upon blocking of apoptosis. Must localize to the mitochondria to induce mitochondrial outer membrane permeabilization and apoptosis (By similarity).
Database Links:	Entrez Gene: 666?Human Omim: 605404?Human SwissProt: Q9UMX3?Human Unigene: 293753?Human
Synonyms:	Bcl 2 related ovarian killer protein Antibody Bcl-2-like protein 9 Antibody Bcl-2-related ovarian killer protein Antibody BCL2 related ovarian killer Antibody Bcl2-L-9 Antibody BCL2L9 Antibody Bok Antibody BOKL Antibody BOK_HUMAN Antibody Hbok Antibody MGC4631 Antibody
Information:	Target information shown above is from the UniProt Consortium.