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Anti-BNIP3L Antibody

品牌：Antibodies

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規(guī)格：100μl

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Anti-BNIP3L Antibody

商品詳情參考文獻相關(guān)資料

Overview

Name:	Anti-BNIP3L Antibody See all BNIP3L primary antibodies
Description:	Rabbit polyclonal antibody to BNIP3L
Specificity:	The antibody detects endogenous levels of total BNIP3L protein.
Applications:	IHC
Reactivity:	Human, Mouse
Immunogen:	Synthetic peptide corresponding to a region derived from internal residues of human BCL2 / adenovirus E1B 19kDa interacting protein 3-like
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	1.6mg / ml
Formulation:	Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage:	Store at -20?C

Target

Function:	Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor.
Sequence Similarities:	Belongs to the NIP3 family.
Post-Translational Modification:	Undergoes progressive proteolysis to an 11 kDa C-terminal fragment, which is blocked by the proteasome inhibitor lactacystin.
Cellular Location:	Nucleus envelope. Endoplasmic reticulum. Mitochondrion outer membrane. Membrane. Colocalizes with SPATA18 at the mitochondrion outer membrane.
Database Links:	Entrez Gene: 665?Human Entrez Gene: 12177?Mouse Omim: 605368?Human SwissProt: O60238?Human SwissProt: Q9Z2F7?Mouse Unigene: 131226?Human Unigene: 29820?Mouse Unigene: 347081?Mouse
Synonyms:	Adenovirus E1B19k binding protein B5 Antibody Adenovirus E1B19K-binding protein B5 Antibody BCL2/adenovirus E1B 19 kd protein interacting protein 3a Antibody BCL2/adenovirus E1B 19 kDa protein interacting protein 3A Antibody BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like Antibody BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A Antibody BCL2/adenovirus E1B 19kDa interacting protein 3 like Antibody BNI3L_HUMAN Antibody BNIP3a Antibody BNIP3H Antibody BNIP3L Antibody BNIP3L protein Antibody NIP3 like protein X Antibody NIP3-like protein X Antibody NIP3L Antibody NIX Antibody
Information:	Target information shown above is from the UniProt Consortium.