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Anti-BMPR1A Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-BMPR1A Antibody

商品詳情參考文獻相關(guān)資料

Overview

Name:	Anti-BMPR1A Antibody See all BMPR1A primary antibodies
Description:	Rabbit polyclonal antibody to BMPR1A
Specificity:	BMPR1A pAb detects endogenous levels of BMPR1A protein.
Applications:	WB
Reactivity:	Human, Mouse, Rat
Immunogen:	A synthetic peptide corresponding to residues in Human BMPR1A.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 60 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.

Target

Function:	On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6.
Tissue Specificity:	Highly expressed in skeletal muscle.
Involvement in Disease:	Juvenile polyposis syndrome: Autosomal dominant gastrointestinal hamartomatous polyposis syndrome in which patients are at risk for developing gastrointestinal cancers. The lesions are typified by a smooth histological appearance, predominant stroma, cystic spaces and lack of a smooth muscle core. Multiple juvenile polyps usually occur in a number of Mendelian disorders. Sometimes, these polyps occur without associated features as in JPS; here, polyps tend to occur in the large bowel and are associated with an increased risk of colon and other gastrointestinal cancers. Polyposis syndrome, mixed hereditary 2: A disease is characterized by atypical juvenile polyps, colonic adenomas, and colorectal carcinomas.
Sequence Similarities:	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Cellular Location:	Membrane.
Synonyms:	10q23del Antibody Activin A receptor type II like kinase 3 Antibody Activin receptor like kinase 3 Antibody Activin receptor-like kinase 3 Antibody ACVRLK 3 Antibody ACVRLK3 Antibody ALK 3 Antibody ALK-3 Antibody ALK3 Antibody BMP type-1A receptor Antibody Bmpr Antibody BMPR 1A Antibody BMPR-1A Antibody BMPR1A Antibody BMR1A_HUMAN Antibody Bone morphogenetic protein receptor type IA Antibody Bone morphogenetic protein receptor type IA precursor Antibody Bone morphogenetic protein receptor type-1A Antibody BR 1a Antibody BR1a Antibody CD 292 Antibody CD292 Antibody CD292 antigen Antibody EC 2.7.11.30 Antibody Serine threonine protein kinase receptor R5 Antibody Serine threonine protein kinase receptor R5 precursor Antibody Serine/threonine-protein kinase receptor R5 Antibody SKR 5 Antibody SKR5 Antibody zBMPR IA Antibody zBMPRIA Antibody
Information:	Target information shown above is from the UniProt Consortium.