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Anti-BLK Antibody

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Anti-BLK Antibody

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Overview

Name:	Anti-BLK Antibody See all BLK primary antibodies
Description:	Rabbit polyclonal antibody to BLK
Specificity:	The antibody detects endogenous levels of total BLK protein.
Applications:	WB, IHC
Reactivity:	Human
Immunogen:	Fusion protein corresponding to residues near the C terminal of human B lymphoid tyrosine kinase
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	1mg / ml
Formulation:	Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage:	Store at -20?C

Target

Function:	Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199', as well as CD79B at 'Tyr-196' and 'Tyr-207'. Phosphorylates also the immunoglobulin G receptors FCGR2A, FCGR2B and FCGR2C. With FYN and LYN, plays an essential role in pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation. Contributes also to BTK activation by indirectly stimulating BTK intramolecular autophosphorylation. In pancreatic islets, acts as a modulator of beta-cells function through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose.
Tissue Specificity:	Expressed in lymphatic organs, pancreatic islets, Leydig cells, striate ducts of salivary glands and hair follicles.
Involvement in Disease:	Maturity-onset diabetes of the young 11: A form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early *****hood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.
Sequence Similarities:	Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
Post-Translational Modification:	Phosphorylated on tyrosine residues after antibody-mediated surface engagement of the B-cell antigen receptor (BCR).
Cellular Location:	Cell membrane. Present and active in lipid rafts. Membrane location is required for the phosphorylation of CD79A and CD79B (By similarity).
Database Links:	Entrez Gene: 640?Human Omim: 191305?Human SwissProt: P51451?Human Unigene: 146591?Human
Synonyms:	B lymphocyte kinase Antibody B lymphoid tyrosine kinase Antibody BLK Antibody BLK nonreceptor tyrosine kinase Antibody BLK_HUMAN Antibody EC 2.7.10.2 Antibody MGC 10442 Antibody MGC10442 Antibody MODY 11 Antibody MODY11 Antibody P55 BLK Antibody p55-BLK Antibody Tyrosine kinase B lymphocyte specific Antibody Tyrosine protein kinase Antibody Tyrosine-protein kinase BLK Antibody
Information:	Target information shown above is from the UniProt Consortium.