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Anti-bisphosphoglycerate mutase Antibody

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Anti-bisphosphoglycerate mutase Antibody

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Anti-bisphosphoglycerate mutase Antibody

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Overview

Name:	Anti-bisphosphoglycerate mutase Antibody See all bisphosphoglycerate mutase primary antibodies
Description:	Rabbit polyclonal antibody to bisphosphoglycerate mutase
Applications:	WB, IF
Reactivity:	Human
Immunogen:	Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 216 of Human BPGM
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Purified by antigen-affinity chromatography.
Formulation:	Supplied in 0.1M Tris-buffered saline with 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
Storage:	Store at -20?C for long term preservation (recommended). Store at 4?C for short term use.

Target

Function:	Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3-bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.1) activity.
Tissue Specificity:	Expressed in red blood cells. Expressed in non-erythroid cells of the placenta; present in the syncytiotrophoblast layer of the placental villi at the feto-maternal interface (at protein level).
Involvement in Disease:	Bisphosphoglycerate mutase deficiency: A disease characterized by hemolytic anemia, splenomegaly, cholelithiasis and cholecystitis.
Sequence Similarities:	Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Post-Translational Modification:	Glycation of Lys-159 in diabetic patients inactivates the enzyme.
Database Links:	Entrez Gene: 669?Human Omim: 613896?Human SwissProt: P07738?Human Unigene: 198365?Human
Synonyms:	2 Antibody 2,3-bisphosphoglycerate mutase Antibody 2,3-bisphosphoglycerate mutase, erythrocyte Antibody 2,3-bisphosphoglycerate synthase Antibody 2,3-diphosphoglycerate mutase Antibody 3-bisphosphoglycerate mutase Antibody 3-bisphosphoglycerate synthase Antibody 3-diphosphoglycerate mutase Antibody Ab2 098 Antibody AI323730 Antibody AL022789 Antibody Bisphosphoglycerate mutase Antibody BPG dependent PGAM Antibody BPG-dependent PGAM Antibody BPGM Antibody C86192 Antibody DPGM Antibody erythrocyte Antibody Erythrocyte 2,3 bisphosphoglycerate mutase Antibody PMGE_HUMAN Antibody
Information:	Target information shown above is from the UniProt Consortium.