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Anti-Bcl-X (phospho-T47) Antibody

品牌：Antibodies

貨號(hào)：

規(guī)格：50μl

貨期：

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Anti-Bcl-X (phospho-T47) Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Name:	Anti-Bcl-X (phospho-T47) Antibody See all Bcl-X primary antibodies
Description:	Rabbit polyclonal antibody to Bcl-X (phospho-T47)
Specificity:	p-Bcl-X (T47) pAb detects endogenous levels of Bcl-X protein only when phosphorylated at Thr47.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic phosphopeptide derived from human Bcl-X around the phosphorylation site of Threonine 47.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 26 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Function:	Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.
Tissue Specificity:	Bcl-X(S) is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X(L) is found in tissues containing long-lived postmitotic cells, such as ***** brain.
Sequence Similarities:	Belongs to the Bcl-2 family.
Post-Translational Modification:	Proteolytically cleaved by caspases during apoptosis. The cleaved protein, lacking the BH4 motif, has pro-apoptotic activity.
Cellular Location:	Mitochondrion inner membrane. Mitochondrion outer membrane. Mitochondrion matrix. Cytoplasmic vesicle > Secretory vesicle > Synaptic vesicle membrane. Cytoplasm > Cytosol. Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome. Nucleus membrane. After neuronal stimulation, translocates from cytosol to synaptic vesicle and mitochondrion membrane in a calmodulin-dependent manner (By similarity). Localizes to the centrosome when phosphorylated at Ser-49.