BAI-1 (Q732) pAb detects endogenous levels of BAI-1 protein.
Applications:
WB, IHC, IF
Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic peptide, corresponding to amino acids 711-760 of Human BAI-1.
Host:
Rabbit
Clonality:
Polyclonal
Conjugate:
Unconjugated
Molecular Weight:
~ 174 kDa
Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Target
Function:
Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Likely to be a potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53 signal in suppression of glioblastoma. May function in cell adhesion and signal transduction in the brain.
Tissue Specificity:
Specifically expressed in brain. Reduced or no expression is observed in some glioblastoma cell lines and cancer tissues. No expression in astrocytes.
Sequence Similarities:
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
Post-Translational Modification:
The endogenous protein is proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.
Cellular Location:
Cell membrane.
Likely to be concentrated at cell-cell adhesion sites.
Database Links:
Entrez Gene: 575?Human
Entrez Gene: 107831?Mouse
Entrez Gene: 362931?Rat
Omim: 602682?Human
SwissProt: O14514?Human
SwissProt: Q3UHD1?Mouse
Unigene: 194654?Human
Unigene: 43133?Mouse
Synonyms:
B830018M07Rik Antibody
BAI 1 Antibody
BAI1 Antibody
BAI1_HUMAN Antibody
Brain specific angiogenesis inhibitor 1 Antibody
Brain-specific angiogenesis inhibitor 1 Antibody
GDAIF Antibody
KIAA4089 Antibody
mKIAA4089 Antibody
R75078 Antibody
Information:
Target information shown above is from the UniProt Consortium.