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Anti-Bad (phospho-S91) Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-Bad (phospho-S91) Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-Bad (phospho-S91) Antibody See all Bad primary antibodies
Description:	Rabbit polyclonal antibody to Bad (phospho-S91)
Specificity:	p-Bad (S91) pAb detects endogenous levels of Bad protein only when phosphorylated at Ser91.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic phosphopeptide derived from human Bad around the phosphorylation site of Serine 91.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 24 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.
Tissue Specificity:	Expressed in a wide variety of tissues.
Sequence Similarities:	Belongs to the Bcl-2 family.
Post-Translational Modification:	Phosphorylated on one or more of Ser-75, Ser-99, Ser-118 and Ser-134 in response to survival stimuli, which blocks its pro-apoptotic activity. Phosphorylation on Ser-99 or Ser-75 promotes heterodimerization with 14-3-3 proteins. This interaction then facilitates the phosphorylation at Ser-118, a site within the BH3 motif, leading to the release of Bcl-X(L) and the promotion of cell survival. Ser-99 is the major site of AKT/PKB phosphorylation, Ser-118 the major site of protein kinase A (CAPK) phosphorylation. Phosphorylation at Ser-99 by PKB/AKT1 is almost completely blocked by the apoptotic C-terminus cleavage product of PKN2 generated by caspases-3 activity during apoptosis.
Cellular Location:	Mitochondrion outer membrane. Cytoplasm. Colocalizes with HIF3A in the cytoplasm (By similarity). Upon phosphorylation, locates to the cytoplasm.
Database Links:	Entrez Gene: 572?Human Entrez Gene: 12015?Mouse Entrez Gene: 64639?Rat Omim: 603167?Human SwissProt: Q92934?Human SwissProt: Q61337?Mouse SwissProt: O35147?Rat Unigene: 370254?Human Unigene: 4387?Mouse Unigene: 36696?Rat
Synonyms:	AI325008 Antibody Bad Antibody BAD_HUMAN Antibody BBC 2 Antibody BBC2 Antibody BBC6 Antibody Bcl 2 Antagonist of Cell Death Antibody Bcl 2 Binding Component 6 Antibody BCL X / BCL 2 Binding Protein Antibody BCL X Binding Protein Antibody Bcl XL/Bcl 2 Associated Death Promoter Antibody Bcl-2-binding component 6 Antibody Bcl-2-like protein 8 Antibody Bcl-XL/Bcl-2-associated death promoter Antibody Bcl2 antagonist of cell death Antibody BCL2 antagonist of cell death protein Antibody BCL2 associated agonist of cell death Antibody Bcl2 Associated Death Promoter Antibody BCL2 binding component 6 Antibody BCL2 binding protein Antibody Bcl2 Like 8 Protein Antibody Bcl2-L-8 Antibody BCL2L8 Antibody Proapoptotic BH3 Only Protein Antibody
Information:	Target information shown above is from the UniProt Consortium.