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Anti-BAD (Phospho-Ser91 / 128) Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-BAD (Phospho-Ser91 / 128) Antibody

商品詳情參考文獻相關資料

Overview

Name:	Anti-BAD (Phospho-Ser91 / 128) Antibody See all BAD primary antibodies
Description:	Rabbit polyclonal antibody to BAD (Phospho-Ser91 / 128)
Specificity:	The antibody detects endogenous levels of BAD only when phosphorylated at serine 91 / serine 128.
Applications:	WB, IHC
Dilutions:	Western blotting: 1:500~1:1000Immunohistochemistry: 1:50~1:100
Reactivity:	Human, Mouse, Rat
Immunogen:	Peptide sequence around phosphorylation site of Serine 91 (E-P-S(p)-P-F) derived from Human BAD or Serine 128 (E-P-S(p)-P-F) derived from Mouse BAD.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Concentration:	1.0mg / ml
Formulation:	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20?C / 1 year

Target

Function:	Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.
Tissue Specificity:	Expressed in a wide variety of tissues.
Sequence Similarities:	Belongs to the Bcl-2 family.
Post-Translational Modification:	Phosphorylated on one or more of Ser-75, Ser-99, Ser-118 and Ser-134 in response to survival stimuli, which blocks its pro-apoptotic activity. Phosphorylation on Ser-99 or Ser-75 promotes heterodimerization with 14-3-3 proteins. This interaction then facilitates the phosphorylation at Ser-118, a site within the BH3 motif, leading to the release of Bcl-X(L) and the promotion of cell survival. Ser-99 is the major site of AKT/PKB phosphorylation, Ser-118 the major site of protein kinase A (CAPK) phosphorylation. Phosphorylation at Ser-99 by PKB/AKT1 is almost completely blocked by the apoptotic C-terminus cleavage product of PKN2 generated by caspases-3 activity during apoptosis.
Cellular Location:	Mitochondrion outer membrane. Cytoplasm. Colocalizes with HIF3A in the cytoplasm (By similarity). Upon phosphorylation, locates to the cytoplasm.
Database Links:	Entrez Gene: 572?Human Entrez Gene: 12015?Mouse Entrez Gene: 64639?Rat Omim: 603167?Human SwissProt: Q92934?Human SwissProt: Q61337?Mouse SwissProt: O35147?Rat Unigene: 370254?Human Unigene: 4387?Mouse Unigene: 36696?Rat
Synonyms:	AI325008 Antibody Bad Antibody BAD_HUMAN Antibody BBC 2 Antibody BBC2 Antibody BBC6 Antibody Bcl 2 Antagonist of Cell Death Antibody Bcl 2 Binding Component 6 Antibody BCL X / BCL 2 Binding Protein Antibody BCL X Binding Protein Antibody Bcl XL/Bcl 2 Associated Death Promoter Antibody Bcl-2-binding component 6 Antibody Bcl-2-like protein 8 Antibody Bcl-XL/Bcl-2-associated death promoter Antibody Bcl2 antagonist of cell death Antibody BCL2 antagonist of cell death protein Antibody BCL2 associated agonist of cell death Antibody Bcl2 Associated Death Promoter Antibody BCL2 binding component 6 Antibody BCL2 binding protein Antibody Bcl2 Like 8 Protein Antibody Bcl2-L-8 Antibody BCL2L8 Antibody Proapoptotic BH3 Only Protein Antibody
Information:	Target information shown above is from the UniProt Consortium.