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Anti-Aurora A/B Kinase Antibody

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Anti-Aurora A/B Kinase Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-Aurora A/B Kinase Antibody See all Aurora A primary antibodies
Description:	Mouse monoclonal (5A12) antibody to Aurora A + B Kinase.
Applications:	WB, ICC/IF, IHC
Dilutions:	WB: 1:1,000-1;2,000. ICC/IF or IHC: 1:1,000-1:2,000.
Reactivity:	Human, Horse, Cow, Porcine, Chicken, Rat, Mouse
Immunogen:	Full length recombinant human Aurora A protein expressed in and purified from E. coli.
Host:	Mouse
Clonality:	Monoclonal
Clone:	5A12
Isotype:	IgG1
Conjugate:	Unconjugated
Purification:	Immunogen affinity purified.
Concentration:	1 mg/ml
Product Form:	Liquid
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizating p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity (By similarity). Necessary for proper cilia disassembly prior to mitosis (By similarity). Interacts with SIRT2 (By similarity).
Tissue Specificity:	Detected in neurons in brain cortex and hippocampus (at protein level). Expressed in mammary gland and tumor.
Sequence Similarities:	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
Post-Translational Modification:	Activated by phosphorylation at Thr-281; this brings about a change in the conformation of the activation segment. Phosphorylation at Thr-281 varies during the cell cycle and is highest during M phase. Autophosphorylated at Thr-281 upon TPX2 binding. Thr-281 can be phosphorylated by several kinases, including PAK and PKA. Protein phosphatase type 1 (PP1) binds AURKA and inhibits its activity by dephosphorylating Thr-281 during mitosis. Phosphorylation at Ser-335 decreases the kinase activity. PPP2CA controls degradation by dephosphorylating Ser-52 at the end of mitosis (By similarity). Phosphorylated in embryonic brain neurons.
Cellular Location:	Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome. Cytoplasm > Cytoskeleton > Spindle pole. Cytoplasm > Cytoskeleton > Cilium basal body. Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome > Centriole. Localizes on centrosomes in interphase cells and at each spindle pole in mitosis. Associates with both the pericentriolar material (PCM) and centrioles. Detected at the neurite hillock in developing neurons. Colocalized with SIRT2 at centrosome.
Database Links:	Entrez Gene: 6790?Human Entrez Gene: 20878?Mouse Entrez Gene: 261730?Rat Omim: 603072?Human SwissProt: O14965?Human SwissProt: P97477?Mouse SwissProt: P59241?Rat Unigene: 250822?Human Unigene: 249363?Mouse Unigene: 161874?Rat
Synonyms:	AIK Antibody ARK-1 Antibody ARK1 Antibody AURA Antibody Aurka Antibody Aurora 2 Antibody Aurora A Antibody Aurora kinase A Antibody Aurora-related kinase 1 Antibody Aurora/IPL1 like kinase Antibody Aurora/IPL1-related kinase 1 Antibody AURORA2 Antibody Breast tumor-amplified kinase Antibody BTAK Antibody hARK1 Antibody IAK Antibody IPL1 related kinase Antibody MGC34538 Antibody OTTHUMP00000031340 Antibody OTTHUMP00000031341 Antibody OTTHUMP00000031342 Antibody OTTHUMP00000031343 Antibody OTTHUMP00000031344 Antibody OTTHUMP00000031345 Antibody OTTHUMP00000166071 Antibody OTTHUMP00000166072 Antibody PPP1R47 Antibody Protein phosphatase 1, regulatory subunit 47 Antibody Serine/threonine kinase 15 Antibody Serine/threonine kinase 6 Antibody Serine/threonine-protein kinase 15 Antibody Serine/threonine-protein kinase 6 Antibody Serine/threonine-protein kinase aurora-A Antibody STK15 Antibody STK6 Antibody STK6_HUMAN Antibody STK7 Antibody
Information:	Target information shown above is from the UniProt Consortium.