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Anti-ATP6AP2 Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-ATP6AP2 Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-ATP6AP2 Antibody See all ATP6AP2 primary antibodies
Description:	Rabbit polyclonal antibody to ATP6AP2.
Applications:	WB, IHC, IF
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:100.
Reactivity:	Human
Immunogen:	Recombinant protein of human ATP6AP2.
Protein Length:	350
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Functions as a renin and prorenin cellular receptor. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS).
Tissue Specificity:	Expressed in brain, heart, placenta, liver, kidney and pancreas. Barely detectable in lung and skeletal muscles. In the kidney cortex it is restricted to the mesangium of glomeruli. In the coronary and kidney artery it is expressed in the subendothelium, associated to smooth muscles where it colocalizes with REN. Expressed in vascular structures and by syncytiotrophoblast cells in the mature fetal placenta.
Involvement in Disease:	Mental retardation, X-linked, with epilepsy: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRXE patients manifest mild to moderate mental retardation associated with epilepsy, delays in motor milestones and speech acquisition in infancy. Parkinsonism with spasticity, X-linked: A syndrome characterized by parkinsonian features, such as cogwheel rigidity, resting tremor and bradykinesia, and variably penetrant spasticity.
Post-Translational Modification:	Phosphorylated.
Cellular Location:	Membrane.
Database Links:	Entrez Gene: 10159?Human Omim: 300556?Human SwissProt: O75787?Human Unigene: 495960?Human
Synonyms:	APT6M8 9 Antibody APT6M8-9 Antibody ATP6AP2 Antibody ATP6IP2 Antibody ATP6M8-9 Antibody ATPase H(+)-transporting lysosomal accessory protein 2 Antibody ATPase H(+)-transporting lysosomal-interacting protein 2 Antibody ATPase H+ transporting lysosomal accessory protein 2 Antibody ATPase H+ transporting lysosomal interacting protein 2 Antibody ATPase H+ transporting lysosomal vacuolar proton pump membrane sector associated protein M8 9 Antibody ATPase membrane sector associated protein M8 9 Antibody ATPase, H+ transporting, lysosomal (vacuolar proton pump) membrane sector associated protein M8 9 Antibody CAPER Antibody ELDF10 Antibody Embryonic liver differentiation factor 10 Antibody ER localized type I transmembrane adaptor Antibody ER-localized type I transmembrane adaptor Antibody HT028 Antibody M8 9 Antibody M8-9 Antibody MGC99577 Antibody MRXE Antibody MSTP009 Antibody N14F Antibody Renin receptor Antibody Renin/prorenin receptor Antibody RENR_HUMAN Antibody V ATPase M8 9 subunit Antibody V ATPase M8.9 subunit Antibody V-ATPase M8.9 subunit Antibody Vacuolar ATP synthase membrane sector associated protein M8 9 Antibody Vacuolar ATP synthase membrane sector-associated protein M8-9 Antibody vacuolar proton ATP synthase membrane sector associated protein M8 9 Antibody XMRE Antibody
Information:	Target information shown above is from the UniProt Consortium.