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Anti-ATG4A Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-ATG4A Antibody

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Overview

Name:	Anti-ATG4A Antibody See all ATG4A primary antibodies
Description:	Rabbit polyclonal antibody to ATG4A
Specificity:	The antibody detects endogenous levels of total ATG4A protein.
Applications:	IHC, IF
Reactivity:	Human, Mouse
Immunogen:	Synthesized peptide derived from C-terminal of human ATG4A.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1.0mg / ml
Formulation:	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20?C

Target

Function:	Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP. Has also an activity of delipidating enzyme for the PE-conjugated forms.
Tissue Specificity:	Widely expressed, at a low level, and the highest expression is observed in skeletal muscle and brain. Also detected in fetal liver.
Sequence Similarities:	Belongs to the peptidase C54 family.
Cellular Location:	Cytoplasm.
Database Links:	Entrez Gene: 115201?Human Entrez Gene: 666468?Mouse Omim: 300663?Human SwissProt: Q8WYN0?Human SwissProt: Q8C9S8?Mouse Unigene: 8763?Human Unigene: 102230?Mouse Unigene: 393320?Mouse
Synonyms:	AI627006 Antibody APG4 autophagy 4 homolog A Antibody Apg4a Antibody ATG4 autophagy related 4 homolog A Antibody ATG4 autophagy related 4 homolog A (S. cerevisiae) Antibody ATG4A Antibody Atg4al Antibody ATG4A_HUMAN Antibody AUT like 2 cysteine endopeptidase Antibody AUT-like 2 cysteine endopeptidase Antibody Autl2 Antibody Autophagin 2 Antibody Autophagin-2 Antibody Autophagy related 4A cysteine peptidase Antibody Autophagy related cysteine endopeptidase 2 Antibody Autophagy related protein 4 homolog A Antibody Autophagy-related cysteine endopeptidase 2 Antibody Autophagy-related protein 4 homolog A Antibody AV169859 Antibody Cysteine protease ATG4A Antibody hAPG4A Antibody MGC107179 Antibody
Information:	Target information shown above is from the UniProt Consortium.