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Anti-ATG12 (S129) Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-ATG12 (S129) Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-ATG12 (S129) Antibody See all ATG12 primary antibodies
Description:	Rabbit polyclonal antibody to ATG12 (S129)
Specificity:	ATG12 (S129) pAb detects endogenous levels of ATG12 protein.
Applications:	WB
Reactivity:	Human, Mouse, Rat
Immunogen:	A synthetic peptide corresponding to residues in Human ATG12.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 15, 50 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.

Target

Function:	Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Plays also a role in translation or delivery of incoming viral RNA to the translation apparatus.
Tissue Specificity:	Ubiquitous.
Sequence Similarities:	Belongs to the ATG12 family.
Post-Translational Modification:	Acetylated by EP300.
Cellular Location:	Cytoplasm. Preautophagosomal structure membrane. TECPR1 recruits the ATG12-ATG5 conjugate to the autolysosomal membrane.
Database Links:	Entrez Gene: 9140?Human Entrez Gene: 67526?Mouse Entrez Gene: 361321?Rat Omim: 609608?Human SwissProt: O94817?Human SwissProt: Q9CQY1?Mouse SwissProt: Q2TBJ5?Rat Unigene: 264482?Human Unigene: 9852?Mouse Unigene: 6224?Rat
Synonyms:	Apg12 Antibody APG12-like Antibody APG12L Antibody ATG12 Antibody ATG12 autophagy related 12 homolog Antibody ATG12 autophagy related 12 homolog (S. cerevisiae) Antibody ATG12_HUMAN Antibody Autophagy 12 Antibody Autophagy-related protein 12 Antibody FBR93 Antibody HAPG12 Antibody Ubiquitin-like protein ATG12 Antibody
Information:	Target information shown above is from the UniProt Consortium.