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Anti-ATF4 (Phospho-Ser245) Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-ATF4 (Phospho-Ser245) Antibody

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Overview

Name:	Anti-ATF4 (Phospho-Ser245) Antibody See all ATF4 primary antibodies
Description:	Rabbit polyclonal antibody to ATF4 (Phospho-Ser245)
Specificity:	The antibody detects endogenous level of ATF4 only when phosphorylated at serine 245.
Applications:	IHC, WB
Reactivity:	Human
Immunogen:	Peptide sequence around phosphorylation site of serine 245 (N-R-S(p)-L-P) derived from Human ATF4.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Concentration:	1.0mg / ml
Formulation:	Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Target

Function:	Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to endoplasmic reticulum (ER) stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. During ER stress response, activates the transcription of NLRP1, possibly in concert with other factors (PubMed:26086088).
Sequence Similarities:	Belongs to the bZIP family.
Post-Translational Modification:	Ubiquitinated by SCF(BTRC) in response to mTORC1 signal, followed by proteasomal degradation and leading to down-regulate expression of SIRT4.
Cellular Location:	Cytoplasm. Cell membrane. Nucleus. Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome. Colocalizes with GABBR1 in hippocampal neuron dendritic membranes (By similarity). Colocalizes with NEK6 at the centrosome (PubMed:20873783).
Database Links:	Entrez Gene: 468?Human Omim: 604064?Human SwissProt: P18848?Human Unigene: 496487?Human
Synonyms:	Activating transcription factor 4 Antibody ATF 4 Antibody ATF-4 Antibody ATF4 Antibody ATF4 protein Antibody ATF4_HUMAN Antibody cAMP-dependent transcription factor ATF-4 Antibody cAMP-responsive element-binding protein 2 Antibody CREB 2 Antibody CREB-2 Antibody CREB2 Antibody Cyclic AMP dependent transcription factor ATF 4 Antibody Cyclic AMP response element binding protein 2 Antibody Cyclic AMP-dependent transcription factor ATF-4 Antibody Cyclic AMP-responsive element-binding protein 2 Antibody DNA binding protein TAXREB67 Antibody DNA-binding protein TAXREB67 Antibody Tax Responsive Enhancer Element B67 Antibody Tax-responsive enhancer element-binding protein 67 Antibody TaxREB67 Antibody TXREB Antibody
Information:	Target information shown above is from the UniProt Consortium.