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Anti-ATF-7 (F74) Antibody

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規(guī)格：50μl

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Anti-ATF-7 (F74) Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-ATF-7 (F74) Antibody See all ATF7 primary antibodies
Description:	Rabbit polyclonal antibody to ATF-7 (F74)
Specificity:	ATF-7 (F74) pAb detects endogenous levels of ATF-7 protein.
Applications:	WB, IHC, IF
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 40-90 of Human ATF-7.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 35, 53 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family.
Tissue Specificity:	Expressed in heart, lung and skeletal muscle. Isoform 4 is expressed in various tissues including heart, brain, placenta, lung and skeletal muscle. Highest levels in skeletal muscle. Lowest in lung and placenta.
Sequence Similarities:	Belongs to the bZIP family.
Post-Translational Modification:	On EGF stimulation, phosphorylated first on Thr-53 allowing subsequent phosphorylation on Thr-51. This latter phosphorylation prevents sumoylation, increases binding to TAF12 and enhances transcriptional activity.
Cellular Location:	Nucleus. Nucleus > Nucleoplasm. Mainly nucleoplasmic. Restricted distribution to the perinuculear region. The sumoylated form locates to the nuclear periphery.
Database Links:	Entrez Gene: 11016?Human Entrez Gene: 223922?Mouse Entrez Gene: 315333?Rat Omim: 606371?Human SwissProt: P17544?Human SwissProt: Q8R0S1?Mouse Unigene: 12286?Human Unigene: 208714?Mouse Unigene: 475149?Mouse Unigene: 219706?Rat
Synonyms:	1110012F10Rik Antibody 9430065F09Rik Antibody Activating transcription factor 7 Antibody AI549878 Antibody ATF7 Antibody Atf7 protein Antibody ATF7_HUMAN Antibody ATFA Antibody C130020M04Rik Antibody cAMP-dependent transcription factor ATF-7 Antibody Cyclic AMP-dependent transcription factor ATF 7 Antibody Cyclic AMP-dependent transcription factor ATF-7 Antibody MGC31554 Antibody MGC57182 Antibody Transcription factor ATF A Antibody Transcription factor ATF-A Antibody
Information:	Target information shown above is from the UniProt Consortium.