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Anti-ATF-5 (Acetyl-Lys29) Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-ATF-5 (Acetyl-Lys29) Antibody

商品詳情參考文獻相關(guān)資料

Overview

Name:	Anti-ATF-5 (Acetyl-Lys29) Antibody See all ATF5 primary antibodies
Description:	Rabbit polyclonal antibody to ATF-5 (Acetyl-Lys29)
Specificity:	Acetyl-ATF-5 (K29) Polyclonal Antibody detects endogenous levels of ATF-5 protein only when acetylated at K29.
Applications:	WB, ELISA
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthesized peptide derived from the human ATF-5 around the acetylation site of K29.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1mg / ml
Formulation:	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage:	Store at -20?C / 1 year

Target

Function:	Transcription factor that either stimulates or represses gene transcription through binding of different DNA regulatory elements such as cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), ATF5-specific response element (ARE) (consensus: 5'-C[CT]TCT[CT]CCTT[AT]-3') but also the amino acid response element (AARE), present in many viral and cellular promoters. Critically involved, often in a cell type-dependent manner, in cell survival, proliferation, and differentiation (PubMed:10373550, PubMed:15358120, PubMed:21212266, PubMed:20654631). Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4 (PubMed:15358120). Important regulator of the cerebral cortex formation, functions in cerebral cortical neuroprogenitor cells to maintain proliferation and to block differentiation into neurons. Must be down-regulated in order for such cells to exit the cycle and differentiate (By similarity). Participates in the pathways by which SHH promotes cerebellar granule neuron progenitor cells proliferation (By similarity). Critical for survival of mature olfactory sensory neurons (OSN), directs expression of OSN-specific genes (By similarity). May be involved in osteogenic differentiation (PubMed:22442021). Promotes cell proliferation and survival by inducing the expression of EGR1 sinergistically with ELK1. Once acetylated by EP300, binds to ARE sequences on target genes promoters, such as BCL2 and EGR1 (PubMed:21791614). Plays an anti-apoptotic role through the transcriptional regulation of BCL2, this function seems to be cell type-dependent (By similarity). Cooperates with NR1I3/CAR in the transcriptional activation of CYP2B6 in liver (PubMed:18332083). In hepatic cells, represses CRE-dependent transcription and inhibits proliferation by blocking at G2/M phase (PubMed:22528486, PubMed:18701499). May act as a negative regulator of IL1B transduction pathway in liver (PubMed:24379400). Upon IL1B stimulus, cooperates with NLK to activate the transactivation activity of C/EBP subfamily members (PubMed:25512613). Besides its function of transcription factor, acts as a cofactor of CEBPB to activate CEBPA and promote adipocyte differentiation (PubMed:24216764). Regulates centrosome dynamics in a cell-cycle- and centriole-age-dependent manner. Forms 9-foci symmetrical ring scaffold around the mother centriole to control centrosome function and the interaction between centrioles and pericentriolar material (PubMed:26213385).
Tissue Specificity:	Widely expressed with higher expression levels in liver.
Sequence Similarities:	Belongs to the bZIP family.
Post-Translational Modification:	Ubiquitinated by CDC34 and UBE2B in order to be degraded by the proteasome. Cisplatin inhibits ubiquitination and proteasome-mediated degradation by inhibiting the interaction with CDC34 (PubMed:18458088). Ubiquitination and degradation by the proteasome are inhibited by NLK in a kinase-independent manner (PubMed:25512613).
Cellular Location:	Cytoplasm. Nucleus. Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome. Actively transported to the centrosome and accumulated in the pericentriolar material (PCM) during G1 to M phase via a microtubule-dependent mechanism. During late telophase and cytokinesis, translocates from the centrosome to the midbody.
Database Links:	Entrez Gene: 22809?Human Entrez Gene: 107503?Mouse Entrez Gene: 282840?Rat Omim: 606398?Human SwissProt: Q9Y2D1?Human SwissProt: O70191?Mouse SwissProt: Q6P788?Rat Unigene: 9754?Human Unigene: 389890?Mouse
Synonyms:	Activating transcription factor 5 Antibody Activating transcription factor 5 alpha/beta Antibody Activating transcription factor X Antibody AFTA Antibody ATF 5 Antibody ATF 7 Antibody ATF5 Antibody ATF7 Antibody ATFX Antibody BZIP protein ATF7 Antibody cAMP dependent transcription factor ATF 5 Antibody cAMP dependent transcription factor ATF5 Antibody Cyclic AMP dependent transcription factor ATF 5 Antibody Cyclic AMP dependent transcription factor ATF5 Antibody FLJ34666 Antibody HMFN0395 Antibody MGC102397 Antibody NAP1 Antibody NRIF3 associated protein Antibody ODA 10 Antibody Transcription factor ATFx Antibody Transcription factor like protein ODA 10 Antibody Transcription factor like protein ODA10 Antibody
Information:	Target information shown above is from the UniProt Consortium.