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Anti-ASPN Antibody

品牌：Antibodies

貨號：

規(guī)格：100μg

貨期：

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Anti-ASPN Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-ASPN Antibody See all ASPN primary antibodies
Description:	Goat polyclonal antibody to ASPN.
Applications:	ELISA, WB, IF
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide corresponding to Human ASPN (internal region).
Sequence:	C-IHENKVKKIQKDT
Host:	Goat
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	100 μg at 0.5 mg/ml.
Product Form:	Liquid
Formulation:	Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Binds calcium and plays a role in osteoblast-driven collagen biomineralization activity (By similarity). Critical regulator of TGF-beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regulates chondrogenesis in the articular cartilage by blocking the TGF-beta/receptor interaction on the cell surface and inhibiting the canonical TGF-beta/Smad signal. Negatively regulates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system. Inhibits BMP2-induced cytodifferentiation of PDL cells by preventing its binding to BMPR1B/BMP type-1B receptor, resulting in inhibition of BMP-dependent activation of SMAD proteins. Inhibits the interaction between TGFB1 and TGF-beta receptor type II in the presence of heparin/heparan sulfate in vitro.
Tissue Specificity:	Higher expression in heart, also detected in kidney, stomach, testes, and skin but only weakly in lung, skeletal muscle, small intestine, and thymus. Expressed specifically and predominantly in the periodontal ligament (PDL). During tooth development, strong expression is seen in the dental follicle, which is the progenitor tissue that forms cementum, alveolar bone, and the PDL. Expressed in the perichondria of the maxilla, mandible, vertebrae, and long bones. Predominantly expressed in the perichondrium/periosteum of long bones (at protein level).
Sequence Similarities:	Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
Cellular Location:	Secreted > Extracellular space > Extracellular matrix.
Database Links:	Entrez Gene: 54829?Human Entrez Gene: 66695?Mouse Entrez Gene: 306805?Rat Omim: 608135?Human SwissProt: Q9BXN1?Human SwissProt: Q99MQ4?Mouse Unigene: 435655?Human Unigene: 383216?Mouse Unigene: 160633?Rat
Synonyms:	ASPN Antibody ASPN protein Antibody ASPN_HUMAN Antibody Asporin Antibody Asporin (LRR class 1) Antibody Asporin proteoglycan Antibody FLJ20129 Antibody LRR class 1 Antibody Periodontal ligament associated protein 1 Antibody Periodontal ligament-associated protein 1 Antibody PLAP 1 Antibody PLAP-1 Antibody PLAP1 Antibody SLRR 1C Antibody SLRR1C Antibody Small leucine rich protein 1C Antibody
Information:	Target information shown above is from the UniProt Consortium.