夜夜操免费视频,香蕉视频污污在线观看,在线婷婷

您好，歡迎來到拜力生物網(wǎng)站！請登錄注冊

我的訂單 | 聯(lián)系我們 | 在線客服QQ：3012681483 | 客服電話：400-968-7988 | 工作時間：08:30-17:30

主營產(chǎn)品： ELISA試劑盒、抗體、補體血清、兔補體、干擾素、小鼠測溫儀、進口試劑、Quidel代理、Swant代理、PBL Assay Science代理

網(wǎng)站首頁產(chǎn)品中心代理品牌新聞資訊資源中心關(guān)于我們

所在位置：首頁 > 產(chǎn)品中心 > Antibodies > Antibodies產(chǎn)品

訂購信息

上海拜力生物科技公司

Tel:400-968-7988 021-33779008

Anti-PODXL1 Antibody

品牌：Antibodies

貨號：

規(guī)格：100μg

貨期：

應(yīng)用：

咨詢客服

立即購買加入購物車

Anti-PODXL1 Antibody

商品詳情參考文獻相關(guān)資料

Overview

Name:	Anti-PODXL1 Antibody See all PODXL1 primary antibodies
Description:	Rabbit polyclonal antibody to PODXL1
Applications:	DB, ELISA, IHC, IP, WB
Dilutions:	DB: 1:4,000; DB: 1:4,000; ELISA: 1:4,000; Immunoprecipitation: 1:150; Immunoprecipitation: 1:150; Western Blot: 1:500
Reactivity:	Human, Monkey, Mouse, Rat
Immunogen:	Synthetic peptide corresponding amino acid region 200-250 on human PODXL protein.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Concentration:	0.55-0.75 μg/μl in antibody stabilization buffer
Storage:	-20?C for long term storage

Target

Function:	Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up inital epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells.
Tissue Specificity:	Glomerular epithelium cell (podocyte).
Sequence Similarities:	Belongs to the podocalyxin family.
Post-Translational Modification:	N- and O-linked glycosylated. Sialoglycoprotein (By similarity).
Cellular Location:	Apical cell membrane. Cell projection > Lamellipodium. Cell projection > Filopodium. Cell projection > Ruffle. Cell projection > Microvillus. Membrane raft. Membrane. In single attached epithelial cells is restricted to a preapical pole on the free plasma membrane whereas other apical and basolateral proteins are not yet polarized. Colocalizes with SLC9A3R2 at the apical plasma membrane during epithelial polarization. Colocalizes with SLC9A3R1 at the trans-Golgi network (transiently) and at the apical plasma membrane. Its association with the membrane raft is transient. Colocalizes with actin filaments, EZR and SLC9A3R1 in a punctate pattern at the apical cell surface where microvilli form. Colocalizes with EZR and SLC9A3R2 at the apical cell membrane of glomerular epithelium cells (By similarity). Forms granular, punctuated pattern, forming patches, preferentially adopting a polar distribution, located on the migrating poles of the cell or forming clusters along the terminal ends of filipodia establishing contact with the endothelial cells. Colocalizes with the submembrane actin of lamellipodia, particularly associated with ruffles. Colocalizes with vinculin at protrusions of cells. Colocalizes with ITGB1. Colocalizes with PARD3, PRKCI, EXOC5, OCLN, RAB11A and RAB8A in apical membrane initiation sites (AMIS) during the generation of apical surface and luminogenesis (By similarity).