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Anti-Podocin Antibody

品牌：Antibodies

貨號：

規(guī)格：50μl

貨期：

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Anti-Podocin Antibody

商品詳情參考文獻相關(guān)資料

Name:	Anti-Podocin Antibody See all Podocin primary antibodies
Description:	Rabbit polyclonal antibody to Podocin
Specificity:	Podocin pAb detects endogenous levels of Podocin protein.
Applications:	WB
Reactivity:	Human, Mouse, Rat
Immunogen:	A synthetic peptide corresponding to residues in Human Podocin.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 42 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.

Function:	Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton.
Tissue Specificity:	Almost exclusively expressed in the podocytes of fetal and mature kidney glomeruli.
Involvement in Disease:	Nephrotic syndrome 2: A form of nephrotic syndrome, a renal disease clinically characterized by severe proteinuria, resulting in complications such as hypoalbuminemia, hyperlipidemia and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. The disorder is resistant to steroid treatment and progresses to end-stage renal failure in the first or second decades. Some patients show later onset of the disorder.
Sequence Similarities:	Belongs to the band 7/mec-2 family.
Post-Translational Modification:	Isoform 2 is glycosylated.
Cellular Location:	Cell membrane.
Database Links:	Entrez Gene: 7827?Human Entrez Gene: 170484?Mouse Entrez Gene: 170672?Rat Omim: 604766?Human SwissProt: Q9NP85?Human SwissProt: Q91X05?Mouse SwissProt: Q8K4G9?Rat Unigene: 412710?Human Unigene: 289099?Mouse Unigene: 86433?Rat
Synonyms:	nephrosis 2, idiopathic, steroid resistant Antibody Nephrosis 2, idiopathic, steroid resistant (podocin) Antibody NPHS2 Antibody NPHS2 gene Antibody PDCN Antibody Podocin Antibody PODO_HUMAN Antibody SRN1 Antibody
Information:	Target information shown above is from the UniProt Consortium.