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Anti-SMC1A (N-term) Antibody

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Anti-SMC1A (N-term) Antibody

商品詳情參考文獻相關(guān)資料

Overview

Name:	Anti-SMC1A (N-term) Antibody See all SMC1A primary antibodies
Description:	Mouse monoclonal antibody to SMC1A (N-term)
Applications:	WB, IHC, FC
Dilutions:	Western blotting: 1:1000
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant fragment, corresponding to amino acids 2aa-351aa of human SMC1A(N-terminus).
Host:	Mouse
Clonality:	Monoclonal
Isotype:	IgG1
Conjugate:	Unconjugated
Purification:	Purified by antigen-affinity chromatography.
Predicted MW:	150kd
Formulation:	Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol
Storage:	store at -20?C

Target

Function:	Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint.
Involvement in Disease:	Cornelia de Lange syndrome 2: A form of Cornelia de Lange syndrome, a clinically heterogeneous developmental disorder associated with malformations affecting multiple systems. Characterized by facial dysmorphisms, abnormal hands and feet, growth delay, cognitive retardation, hirsutism, gastroesophageal dysfunction and cardiac, ophthalmologic and genitourinary anomalies.
Sequence Similarities:	Belongs to the SMC family. SMC1 subfamily.
Post-Translational Modification:	Phosphorylated by ATM upon ionizing radiation in a NBS1-dependent manner. Phosphorylated by ATR upon DNA methylation in a MSH2/MSH6-dependent manner. Phosphorylation of Ser-957 and Ser-966 activates it and is required for S-phase checkpoint activation.
Cellular Location:	Nucleus. Chromosome. Chromosome > Centromere > Kinetochore. Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. In germ cells, cohesin complex dissociates from chromatin at prophase I, and may be replaced by a meiosis-specific cohesin complex. The phosphorylated form on Ser-957 and Ser-966 associates with chromatin during G1/S/G2 phases but not during M phase, suggesting that phosphorylation does not regulate cohesin function. Integral component of the functional centromere-kinetochore complex at the kinetochore region during mitosis.
Database Links:	Entrez Gene: 8243?Human Entrez Gene: 24061?Mouse Entrez Gene: 63996?Rat Omim: 300040?Human SwissProt: Q14683?Human SwissProt: Q9CU62?Mouse SwissProt: Q9Z1M9?Rat Unigene: 211602?Human
Synonyms:	Chromosome segregation protein SmcB Antibody DXS423E Antibody KIAA0178 Antibody MGC138332 Antibody Sb1.8 Antibody Segregation of mitotic chromosomes 1 Antibody SMC protein 1A Antibody SMC-1-alpha Antibody SMC-1A Antibody SMC1 Antibody SMC1 (structural maintenance of chromosomes 1 yeast) like 1 Antibody SMC1 structural maintenance of chromosomes 1 like 1 Antibody SMC1A Antibody SMC1alpha Antibody SMC1A_HUMAN Antibody SMC1L1 Antibody SMCB Antibody Structural maintenance of chromosomes 1A Antibody Structural maintenance of chromosomes protein 1A Antibody
Information:	Target information shown above is from the UniProt Consortium.